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APOA1 / ApoAI Antibody, Rabbit PAb

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Expression host: E. coli  
  • Slide 1
10686-H07E-50
10686-H07E-100
50 µg 
100 µg 
Add to Cart
Description: Active  
Expression host: Human Cells  
  • Slide 1
10686-H02H-50
10686-H02H-100
50 µg 
100 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
50918-M08H-200
50918-M08H-100
200 µg 
100 µg 
Add to Cart
Description: Active  
Expression host: Human Cells  
  • Slide 1
50918-M02H-200
50918-M02H-100
200 µg 
100 µg 
Add to Cart

MP200887 

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Apolipoprotein A-I/ApoA1 antibody Background

Apolipoprotein A1 (APOA1) is a member of the apolipoprotein family whose members are proteins bind with lipids and form lipoproteins to translate these oil-soluble lipids such as fat and cholesterol through lymphatic and circulatory system. APOA1 is the main component of high density lipoprotein (HDL) in plasma and is involved in the esterification of cholesterol as a cofactor of lecithin-cholesterol acyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters, and thus play a major role in cholesterol efflux from peripheral cells. As a major component of the HDL complex, APOA1 helps to clear cholesterol from arteries. APOA1 is also characterized as a prostacyclin stabilizing factor, and thus may have an anticlotting effect. Defects in encoding gene may result in HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Men carrying a mutation may develop premature coronary artery disease.

Human Apolipoprotein A-I/ApoA1 antibody References
  • Toptas B, et al. (2011) Comparison of lipid profiles with APOA1 MspI polymorphism in obese children with hyperlipidemia. In Vivo. 25(3): 425-30.
  • Haase CL, et al. (2011) Mutation in APOA1 predicts increased risk of ischaemic heart disease and total mortality without low HDL cholesterol levels. J Intern Med. 270(2): 136-46.
  • Wu Z, et al. (2011) The low resolution structure of ApoA1 in spherical high density lipoprotein revealed small angle neutron scattering. J Biol Chem. 286(14): 12495-508.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"