Text Size:AAA

TROP-2 / TACSTD2 Antibody, Rabbit MAb

DatasheetReviewsProtocols
Description: Active  
Expression host: Human Cells  
  • Slide 1
10428-H03H-200
10428-H03H-100
200 µg 
100 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
10428-H08H-200
10428-H08H-100
200 µg 
100 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
50922-M02H-200
50922-M02H-100
200 µg 
100 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
50922-M08H-200
50922-M08H-100
200 µg 
100 µg 
Add to Cart

TROP-2/TACSTD2/TACD2 AntibodyRelated Products

Related Products

Featured Reagent Products

TROP-2/TACSTD2/TACD2 antibody Background

TROP-2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.

Mouse TROP-2/TACSTD2/TACD2 antibody References
  • Ripani E, et al. (1998) Human Trop-2 is a tumor-associated calcium signal transducer. Int J Cancer. 76(5): 671-6.
  • Wang J, et al. (2008) Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers. Mol Cancer Ther. 7(2): 280-5.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"