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CLEC5A / MDL1 / MDL-1 Antibody, Rabbit PAb, Antigen Affinity Purified

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Expression host: Human Cells  
  • Slide 1
80259-R07H-20
80259-R07H-100
20 µg 
100 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
90157-C04H-20
90157-C04H-100
20 µg 
100 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
90157-C07H-20
90157-C07H-100
20 µg 
100 µg 
Add to Cart

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CLEC5A / MDL1 / MDL-1 antibody Background

CLEC5A, also known as MDL1 and MDL-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. CLEC5A with dnax-activation protein 12 and may play a role in cell activation. It also functions as a positive regulator of osteoclastogenesis. CLEC5A acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation .The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.

Rat CLEC5A / MDL1 / MDL-1 antibody References
  • Chen ST. et al., 2008, Nature. 453 (7195): 672-6.
  • Davila S. et al., 2010, Genes Immun. 11 (3): 232-8.
  • Hillier LW. et al., 2003, Nature. 424 (6945): 157-64.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"