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MERTK / Mer Antibody, Rabbit PAb, Antigen Affinity Purified

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Expression host: Human Cells  
  • Slide 1
10298-HCCH-20
10298-HCCH-100
20 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
10298-H03H-200
10298-H03H-100
200 µg 
100 µg 
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Expression host: Baculovirus-Insect Cells  
  • Slide 1
10298-HNCB1-50
10298-HNCB1-20
50 µg 
20 µg 
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Expression host: Baculovirus-Insect Cells  
  • Slide 1
10298-H20B1-50
10298-H20B1-20
50 µg 
20 µg 
Add to Cart
Expression host: Baculovirus-Insect Cells  
  • Slide 1
50514-M20B1-50
50514-M20B1-20
50 µg 
20 µg 
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Expression host: Human Cells  
  • Slide 1
50514-M02H-200
50514-M02H-100
200 µg 
100 µg 
Add to Cart

MERTK/Mer AntibodyRelated Products

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MERTK/Mer antibody Background

&Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. MERTK is localized in membrane and is no expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. This protein is highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver. MERTK regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. MERTK plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Defects in MERTK are the cause of retinitis pigmentosa type 38.

Human MERTK/Mer antibody References
  • Thompson DA, et al. (2002) Retinal dystrophy due to paternal isodisomy for chromosome 1 or chromosome 2, with homoallelism for mutations in RPE65 or MERTK, respectively. Am J Hum Genet. 70 (1): 224-9.
  • Tada A, et al. (2006) Screening of the MERTK gene for mutations in Japanese patients with autosomal recessive retinitis pigmentosa. Mol Vis. 12: 441-4.
  • McHenry CL, et al. (2004) MERTK arginine-844-cysteine in a patient with severe rod-cone dystrophy: loss of mutant protein function in transfected cells. Invest Ophthalmol. Vis Sci. 45 (5): 1456-63.
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