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Epcr / PROCR Antibody, Rabbit PAb, Antigen Affinity Purified

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Expression host: Human Cells  
  • Slide 1
13320-H02H-50
13320-H02H-20
50 µg 
20 µg 
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Expression host: Human Cells  
  • Slide 1
13320-H08H-50
13320-H08H-20
50 µg 
20 µg 
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Expression host: Human Cells  
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50874-M02H-50
50874-M02H-20
50 µg 
20 µg 
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Expression host: Human Cells  
  • Slide 1
50874-M08H-50
50874-M08H-20
50 µg 
20 µg 
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Expression host: Human Cells  
  • Slide 1
80362-R08H-20
80362-R08H-100
20 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
90229-C02H-20
90229-C02H-100
20 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
90229-C08H-50
90229-C08H-20
50 µg 
20 µg 
Add to Cart

Epcr/PROCR AntibodyRelated Products

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Epcr/PROCR antibody Background

Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels), activated protein C is found maily near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case, protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa, turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR, activated protein C performs its cytoprotective effects, acting on the effector substrate PAR-1, protease-activated receptor-1. To a degree, APC's anticoagulant properties are independent of its cytoprotective ones, in that expression of one pathway is not affected by the existence of the other. 

Mouse Epcr/PROCR antibody References
  • Nicolaes GA, et al. (2003). Congenital and acquired activated protein C resistance. Semin Vasc Med. 3 (1): 33-46.
  • Esmon CT. ( 2003). The protein C pathway. Chest 124 (3): 26-32.
  • Mosnier LO, et al. (2007)The cytoprotective protein C pathway. Blood. 109: 3161-72.
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