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CREB3L1 / OASIS Antibody, Rabbit PAb

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Expression host: Human Cells  
  • Slide 1
12712-H08H-20
12712-H08H-100
20 µg 
100 µg 
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CREB3L1 / OASIS antibody Background

CREB3L1, also known as OASIS, is a cellular transcription factor synthesized as a membrane-bound precursor. It is a putative endoplasmic reticulum (ER) stress sensor in astrocytes with a mechanism of activation. OASIS mRNA expression was detected in pancreatic β-cell lines and rodent islets, and the expression level was up-regulated by ER stress-inducing compounds. CREB3L1 may have a role in pancreas development. CREB3L1 may also play an important role in limiting virus spread by inhibiting proliferation of virus-infected cells. In vitro, CREB3L1 binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE. It may play a role in gliosis.

Human CREB3L1 / OASIS antibody References
  • Denard B. et al., 2011, Cell Host Microbe. 10 (1): 65-74.
  • Debelenko LV. et al., 2011, 50 (12): 1054-62.
  • Vellanki. et al., 2010, Endocrinology. 151 (9): 4146.
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