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Human PCSK1 / NEC1 HEK293 Cell Lysate (WB positive control)

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Expression host: Human Cells  
  • Slide 1
10129-H08H-20
10129-H08H-10
20 µg 
10 µg 
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Reactivity: Human  
Application: ELISA  
    10129-RP02-50
    10129-RP02-200
    10129-RP02-100
    50 µg 
    200 µg 
    100 µg 
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    Reactivity: Human  
    Application: ELISA  
      10129-RP01-400
      10129-RP01-200
      10129-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart

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      PCSK1 lysate_category Background

      Neuroendocrine convertase 1, also known as Prohormone convertase 1, Proprotein convertase 1, PCSK1 and NEC1, is an enzyme which belongs to the peptidase S8 family and Furin subfamily. PCSK1 is an enzyme that performs the proteolytic cleavage of prohormones to their intermediate (or sometimes completely cleaved) forms. It is present only in neuroendocrine cells such as brain, pituitary and adrenal, and most often cleaves after a pair of basic residues within prohormones but can occasionally cleave after a single arginine. It binds to a protein known as proSAAS, which also represents its endogenous inhibitor. PCSK1 is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. PCSK1 substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin. Defects in PCSK1 are the cause of proprotein convertase 1 deficiency (PC1 deficiency). PC1 deficiency is characterized by obesity, hypogonadism, hypoadrenalism, reactive hypoglycemia as well as marked small-intestinal absorptive dysfunction. It is due to impaired processing of prohormones.

      Human PCSK1 lysate_category References
    • Jackson RS. et al., 2003, J. Clin. Invest. 112:1550-60.
    • Farooqi I.S. et al., 2007, J. Clin. Endocrinol. Metab. 92: 3369-73.
    • Benzinou,M. et al., 2008,Nat Genet. 40 (8):943-5.
    • Benzinou M. et al., 2008, Nat. Genet. 40:943-5.
    • Renström F, et al., 2009, Hum. Mol. Genet. 18 (8): 1489-96.
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