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Human BPHL Gene ORF cDNA clone expression plasmid, N-His tag

DatasheetReviewsProtocols
Expression host: E. coli  
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13675-H07E-20
13675-H07E-100
20 µg 
100 µg 
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Reactivity: Human  
Application: ELISA  WB  IHC-P  IP  
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13675-T60-50
13675-T60-200
13675-T60-100
50 µg 
200 µg 
100 µg 
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BPHL cdna-clone Background

BPHL is a member of the serine protease family. BPHL is expressed large quantities in liver and kidney and in minor quantities in heart, intestine and skeletal muscle. BPHL is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. It catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. BPHL also activates valacyclovir to acyclovir. It may play a role in detoxification processes.

Human BPHL cdna-clone References
  • Lai L. et al., 2008, J Biol Chem. 283 (14): 9318-27.
  • Davila S. et al., 2010, Genes Immun. 11 (3): 232-8.
  • Hendrickson SL. et al., 2010, PLoS One. 5 (9): e12862.
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