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Human MCSF Receptor/CSF1R/CD115 Gene ORF cDNA clone expression plasmid, C-Flag tag

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Expression host: Baculovirus-Insect Cells  
  • Slide 1
10161-H20B2-50
10161-H20B2-20
50 µg 
20 µg 
Add to Cart
Description: Active  
Expression host: Human Cells  
  • Slide 1
10161-H03H-200
10161-H03H-100
200 µg 
100 µg 
Add to Cart
Description: Active  
Expression host: Human Cells  
  • Slide 1
10161-H08H-50
10161-H08H-100
50 µg 
100 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
10161-HCCH-200
10161-HCCH-100
200 µg 
100 µg 
Add to Cart
Expression host: Baculovirus-Insect Cells  
  • Slide 1
10161-H20B1-50
10161-H20B1-20
50 µg 
20 µg 
Add to Cart
Description: Active  
Expression host: Human Cells  
  • Slide 1
50059-M08H-50
50059-M08H-100
50 µg 
100 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
50059-M03H-50
50059-M03H-100
50 µg 
100 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
80447-R02H-50
80447-R02H-100
50 µg 
100 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
80447-R08H-50
80447-R08H-100
50 µg 
100 µg 
Add to Cart
Reactivity: Human  
Application: 
  • Slide 1
10161-T24-50
10161-T24-200
10161-T24-100
50 µg 
200 µg 
100 µg 
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Reactivity: Human  
Application: ELISA  IHC-P  
  • Slide 1
  • Slide 1
10161-RP02-50
10161-RP02-200
10161-RP02-100
50 µg 
200 µg 
100 µg 
Add to Cart
Reactivity: Human  
Application: ELISA  
    10161-RP03-50
    10161-RP03-200
    10161-RP03-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10161-MM04-50
    10161-MM04-200
    10161-MM04-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10161-MM12-50
      10161-MM12-200
      10161-MM12-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10161-RP01-400
        10161-RP01-200
        10161-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10161-MM02-50
          10161-MM02-200
          10161-MM02-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart
          Reactivity: Human  
          Application: ELISA  
            10161-R029-50
            10161-R029-100
            50 µg 
            100 µg 
            Add to Cart
            Reactivity: Human  
            Application: FCM  
            • Slide 1
            10161-MM04-F-25
            10161-MM04-F-100
            25 Test 
            100 Tests 
            Add to Cart
            Reactivity: Human  
            Application: ELISA  
              10161-R108-50
              10161-R108-100
              50 µg 
              100 µg 
              Add to Cart
              Reactivity: Mouse  
              Application: ELISA  
                50059-R220-50
                50059-R220-100
                50 µg 
                100 µg 
                Add to Cart
                Reactivity: Mouse  
                Application: ELISA  
                  50059-RP02-50
                  50059-RP02-200
                  50059-RP02-100
                  50 µg 
                  200 µg 
                  100 µg 
                  Add to Cart
                  Reactivity: Mouse  
                  Application: ELISA  
                  • Slide 1
                  50059-RP01-400
                  50059-RP01-200
                  50059-RP01-100
                  400 µg 
                  200 µg 
                  100 µg 
                  Add to Cart
                  Reactivity: Rat  
                  Application: ELISA  
                    80447-RP01-400
                    80447-RP01-200
                    80447-RP01-100
                    400 µg 
                    200 µg 
                    100 µg 
                    Add to Cart
                    Reactivity: Rat  
                    Application: ELISA  
                      80447-T16-50
                      80447-T16-200
                      80447-T16-100
                      50 µg 
                      200 µg 
                      100 µg 
                      Add to Cart

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                      MCSF Receptor/CSF1R/CD115 cdna-clone Background

                      M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein is consisted by an extracellular ligand-binding domain, a single membrane-spanning segment, and an intracellular tyrosine kinase domain. Binding of CSF1 activates the receptor kinase, leading to "autophosphorylation" of receptor subunits and the concomitant phosphorylation of a series of cellular proteins on tyrosine residues. CSF1R is a tyrosine kinase receptor that is absolutely required for macrophage differentiation and thus occupies a central role in hematopoiesis. CSF1 and its receptor (CSF1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. This apparent role for CSF1/CSF1R in normal mammary gland development is very intriguing because this receptor/ligand pair has also been found to be important in the biology of breast cancer in which abnormal expression of CSF1 and its receptor correlates with tumor cell invasiveness and adverse clinical prognosis. Tumor cell expression of CSF1R is under the control of several steroid hormones (glucocorticoids and progestins) and the binding of several bHLH transcription factors, while tumor cell expression of CSF-1 appears to be regulated by other hormones, some of which are involved in normal lactogenic differentiation. However, studies have demonstrated that CSF1 and CSF1R have additional roles in mammary gland development during pregnancy and lactation. The role of CSF1 and CSF1R in normal and neoplastic mammary development that may elucidate potential relationships of growth factor-induced biological changes in the breast during pregnancy and tumor progression.

                      Human MCSF Receptor/CSF1R/CD115 cdna-clone References
                    • Sherr CJ. (1990) The colony-stimulating factor 1 receptor: pleiotropy of signal-response coupling. Lymphokine Res. 9(4): 543-8.
                    • Kacinski BM. (1997) CSF-1 and its receptor in breast carcinomas and neoplasms of the female reproductive tract. Mol Reprod Dev. 46(1): 71-4.
                    • Sapi E, et al. (1999) The role of CSF-1 in normal and neoplastic breast physiology. Proc Soc Exp Biol Med. 220(1): 1-8.
                    • Sapi E. (2004) The role of CSF-1 in normal physiology of mammary gland and breast cancer: an update. Exp Biol Med (Maywood). 229(1): 1-11.
                    • Bonifer C, et al. (2008) The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis. Front Biosci. 13: 549-60.
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