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Human JAML / AMICA HEK293 Cell Lysate (WB positive control)

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Description: Active  
Expression host: Human Cells  
  • Slide 1
10120-H08H-50
10120-H08H-100
50 µg 
100 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
51130-M08H-50
51130-M08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
51130-M02H-50
51130-M02H-100
50 µg 
100 µg 
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Reactivity: Human  
Application: ELISA  
    10120-MM08-50
    10120-MM08-200
    10120-MM08-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10120-MM02-50
    10120-MM02-200
    10120-MM02-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: 
      10120-MM06-50
      10120-MM06-200
      10120-MM06-100
      10120-MM06-1
      50 µg 
      200 µg 
      100 µg 
      1 mg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10120-RP02-50
        10120-RP02-200
        10120-RP02-100
        50 µg 
        200 µg 
        100 µg 
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        Reactivity: Human  
        Application: FCM  
        • Slide 1
        • Slide 1
        10120-MM02-F-25
        10120-MM02-F-100
        25 Test 
        100 Tests 
        Add to Cart
        Reactivity: Human  
        Application: FCM  
        • Slide 1
        10120-MM02-A-25
        10120-MM02-A-100
        25 Test 
        100 Tests 
        Add to Cart
        Reactivity: Human  
        Application: 
          10120-MM05-50
          10120-MM05-200
          10120-MM05-100
          10120-MM05-1
          50 µg 
          200 µg 
          100 µg 
          1 mg 
          Add to Cart
          Reactivity: Human  
          Application: ELISA  
            10120-RP01-400
            10120-RP01-200
            10120-RP01-100
            400 µg 
            200 µg 
            100 µg 
            Add to Cart
            Reactivity: Human  
            Application: FCM  
            • Slide 1
            • Slide 1
            10120-MM02-P-25
            10120-MM02-P-100
            25 Test 
            100 Tests 
            Add to Cart

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            JAML/AMICA1 lysate_category Background

            Junctional adhesion molecules (JAMs) are endothelial and epithelial adhesion molecules involved in the recruitment of circulating leukocytes to inflammatory sites. JAML (Junctional adhesion molecule-like), also known as AMICA1 (Adhesion molecule interacting with CXADR antigen 1), a protein related to the JAM family, is restricted to leukocytes and promotes their adhesion to endothelial cells. It contains 2 extracellular immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic tail involved in activation signaling. Monocytic JAML/AMICA1 plays a critical role in regulating monocyte transendothelial migration (TEM) probably via binding to the endothelial coxsackie and adenovirus receptor (CAR) and other tight junction-associated adhesive molecules. The Expression of JAML/AMICA1 is restricted to the hematopoietic tissues with the exception of liver. JAML may function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, JAML/AMICA1 also enhances myeloid leukemia cell adhesion to endothelial cells.

            Human JAML/AMICA1 lysate_category References
          • Moog-Lutz C, et al. (2003) JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. Blood. 102(9): 3371-8.
          • Luissint AC, et al. (2008) JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation. J Cell Biol. 183(6): 1159-73.
          • Guo YL, et al. (2009) Role of junctional adhesion molecule-like protein in mediating monocyte transendothelial migration. Arterioscler Thromb Vasc Biol. 29(1): 75-83.
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