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Mouse IL12B/IL-12B Gene ORF cDNA clone in cloning vector

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Description: Active  
Expression host: Human Cells  
  • Slide 1
10052-H02H-20
10052-H02H-10
20 µg 
10 µg 
Add to Cart
Description: Active  
Expression host: Human Cells  
  • Slide 1
10052-H08H-500
10052-H08H-5
10052-H08H-20
10052-H08H-100
10052-H08H-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
51004-M02H-50
51004-M02H-20
50 µg 
20 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
51004-MCCH-50
51004-MCCH-20
50 µg 
20 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
51004-M08H-50
51004-M08H-20
50 µg 
20 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
80352-R08H-20
80352-R08H-10
20 µg 
10 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
80352-R02H-20
80352-R02H-10
20 µg 
10 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
65008-T08H-5
65008-T08H-20
65008-T08H-100
5 µg 
20 µg 
100 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
90289-C02H-20
90289-C02H-10
20 µg 
10 µg 
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Reactivity: Human  
Application: ELISA  
    10052-RP03-400
    10052-RP03-200
    10052-RP03-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10052-RP02-50
      10052-RP02-200
      10052-RP02-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10052-MM01-50
        10052-MM01-200
        10052-MM01-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10052-R054-50
          10052-R054-100
          10052-R054-1
          50 µg 
          100 µg 
          1 mg 
          Add to Cart
          Reactivity: Human  
          Application: 
            10052-MM05-50
            10052-MM05-200
            10052-MM05-100
            10052-MM05-1
            50 µg 
            200 µg 
            100 µg 
            1 mg 
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  
              51004-RP01-400
              51004-RP01-200
              51004-RP01-100
              400 µg 
              200 µg 
              100 µg 
              Add to Cart
              Reactivity: Mouse  
              Application: ELISA  
                51004-T16-50
                51004-T16-200
                51004-T16-100
                50 µg 
                200 µg 
                100 µg 
                Add to Cart
                Reactivity: Mouse  
                Application: ELISA  
                  51004-R020-50
                  51004-R020-100
                  50 µg 
                  100 µg 
                  Add to Cart
                  Reactivity: Rat  
                  Application: ELISA  
                    80352-RP01-400
                    80352-RP01-200
                    80352-RP01-100
                    400 µg 
                    200 µg 
                    100 µg 
                    Add to Cart
                    Reactivity: Rat  
                    Application: ELISA  
                      80352-MM01-50
                      80352-MM01-200
                      80352-MM01-100
                      50 µg 
                      200 µg 
                      100 µg 
                      Add to Cart
                      Reactivity: Rat  
                      Application: 
                        80352-R106-50
                        80352-R106-100
                        50 µg 
                        100 µg 
                        Add to Cart
                        Reactivity: Rat  
                        Application: ELISA  IHC-P  
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                        80352-T24-50
                        80352-T24-200
                        80352-T24-100
                        50 µg 
                        200 µg 
                        100 µg 
                        Add to Cart

                        IL12B/IL-12B ELISA Pair Set

                        Detection Limit:
                        SEKB10052-5
                        SEKB10052-15
                        5 Plates 
                        15 Plates 
                        Add to Cart

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                        IL12B/IL-12B cdna-clone Background

                        Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. IL12B/IL-12B is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. IL12B/IL-12B associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity.

                        Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                        Mouse IL12B/IL-12B cdna-clone References
                      • Taoufik Y, et al. (1997) Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect. Blood. 89 (8): 2842-8.
                      • Fantuzzi L, et al. (1996) Induction of interleukin-12 (IL-12) by recombinant glycoprotein gp120 of human immunodeficiency virus type 1 in human monocytes/macrophages: requirement of gamma interferon for IL-12 secretion. J Virol. 70 (6): 4121-4.
                      • Aragane Y, et al. (1995) IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J Immunol. 153 (12): 5366-72.
                      • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"