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Human FACTOR D/Adipsin Gene ORF cDNA clone expression plasmid, C-Flag tag

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Expression host: Human Cells  
  • Slide 1
10160-H08H-20
10160-H08H-10
20 µg 
10 µg 
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Expression host: Human Cells  
  • Slide 1
50539-M08H-50
50539-M08H-20
50 µg 
20 µg 
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Reactivity: Human  
Application: ELISA  
    10160-RP01-400
    10160-RP01-200
    10160-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    Reactivity: Human  
    Application: ELISA  
      10160-MM13-50
      10160-MM13-200
      10160-MM13-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10160-RP02-50
        10160-RP02-200
        10160-RP02-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10160-R005-50
          10160-R005-100
          50 µg 
          100 µg 
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          Reactivity: Mouse  
          Application: ELISA  
            50539-RP01-400
            50539-RP01-200
            50539-RP01-100
            400 µg 
            200 µg 
            100 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  
              50539-R121-50
              50539-R121-100
              50 µg 
              100 µg 
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              Reactivity: Mouse  
              Application: WB  
              • Slide 1
              50539-R104-50
              50539-R104-100
              50 µg 
              100 µg 
              Add to Cart
              Reactivity: Mouse  
              Application: ELISA  
                50539-R110-50
                50539-R110-100
                50 µg 
                100 µg 
                Add to Cart
                Reactivity: Mouse  
                Application: ELISA  
                  50539-T16-50
                  50539-T16-200
                  50539-T16-100
                  50 µg 
                  200 µg 
                  100 µg 
                  Add to Cart

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                  FACTOR D/Adipsin cdna-clone Background

                  Complement factor D, also known as Adipsin, C3 convertase activator, Properdin factor D and CFD is a secreted protein which belongs to the peptidase S1 family. CFD / Adipsin contains one peptidase S1 domain. Complement factor D ( CFD / Adipsin ) is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. Complement factor D ( CFD / Adipsin ) has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Complement factor D ( CFD / Adipsin ) cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Complement factor D ( CFD / Adipsin ) is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency (CFD deficiency) which predisposes to invasive meningococcal disease.

                  Human FACTOR D/Adipsin cdna-clone References
                • Volanakis JE, et al.,1996, Protein Sci. 5 (4): 553-64.
                • Searfoss,G.H et al., 2003, J Biol Chem. 278 (46):46107-16.
                • Ukkola,O. et al., 2003, Eur J Clin Nutr. 57 (9):1073-8.
                • Ronti T, et al., 2006, Clin. Endocrinol. (Oxf) 64 (4): 355-65.
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