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Human CD99L2 Gene ORF cDNA clone expression plasmid, N-His tag

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Description: Active  
Expression host: Human Cells  
  • Slide 1
50526-M08H-50
50526-M08H-100
50 µg 
100 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
50526-M02H-50
50526-M02H-100
50 µg 
100 µg 
Add to Cart
Reactivity: Mouse  
Application: ELISA  
    50526-RP02-50
    50526-RP02-200
    50526-RP02-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Mouse  
    Application: ELISA  
      50526-RP01-400
      50526-RP01-200
      50526-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart

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      CD99L2 cdna-clone Background

      CD99 antigen-like protein 2, also known as MIC2-like protein 1, CD99L2 and MIC2L1, is a single-pass type I  membrane protein which belongs to the CD99 family. CD99L2 is expressed in brain, heart, lung, liver, spleen, kidney, stomach, small intestine, skeletal muscle, ovary, thymus, testis and uterus. Lower expression of CD99L2 is seen in thymus. It is also expressed in E18 uterus and placenta. CD99 and CD99L2 were required for leukocyte extravasation in the cremaster after stimulation with tumor necrosis factor-alpha, where the need for PECAM-1 is known to be bypassed. CD99 and CD99L2 act independently of PECAM-1 in leukocyte extravasation and cooperate in an independent way to help neutrophils overcome the endothelial basement membrane. CD99L2 may function as a homophilic adhesion molecule. It functions in leukocyte-endothelial cell interactions during leukocyte extravasation, and in particular, at the diapedesis step. CD99L2 does not seem to be involved in docking of leukocytes to the vessel wall or in lymphocyte diapedesis.

      Human CD99L2 cdna-clone References
    • Suh, YH. et al., 2003, Gene. 307: 63-76.
    • Park,S.H. Gene 2005, 353 (2):177-88.
    • Schenkel, AR et al., 2007, Cell Commun Adhes. 14 (5):227-37.
    • Bixel, MG. et al., 2010, Blood. 116 (7):1172-84. 
    • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"