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Human Cadherin-6/CDH6 Gene ORF cDNA clone expression plasmid, C-Flag tag

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Expression host: Human Cells  
  • Slide 1
10150-H08H-50
10150-H08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
50985-M08H-50
50985-M08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
80277-R08H-50
80277-R08H-200
50 µg 
200 µg 
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Reactivity: Human  
Application: ELISA  
    10150-RP01-400
    10150-RP01-200
    10150-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    Reactivity: Human  
    Application: ELISA  
      10150-T16-50
      10150-T16-200
      10150-T16-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10150-MM08-50
        10150-MM08-200
        10150-MM08-100
        50 µg 
        200 µg 
        100 µg 
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        Reactivity: Mouse  
        Application: ELISA  
          50985-T16-50
          50985-T16-200
          50985-T16-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart
          Reactivity: Rat  
          Application: 
          • Slide 1
          • Slide 1
          80277-T24-50
          80277-T24-200
          80277-T24-100
          50 µg 
          200 µg 
          100 µg 
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          Cadherin-6/CDH6 cdna-clone Background

          Cadherins are a family of calcium-dependent, cell-cell adhesion molecules that play an important morphoregulatory role in a wide variety of tissues. Alterations in cadherin function have been implicated in tumor progression in a number of adenocarcinomas. Cadherin-6 (CDH6), also known as K-cadherin (KCAD), is a type-II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human Cadherin-6 is synthesized as a 790 aa type I transmembrane glycoprotein that contains a 18 aa signal peptide, a 35 aa propeptide, a 562 aa extracellular region, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain. There are five cadherin domains of approximately 110 aa each in the extracellular region. Cadherin-6 is highly expressed in brain, cerebellum, and kidney, and may contribute to the formation of the segmental structure of the early brain, as well as the development of renal proximal tubules. Weak expression is also detected lung, pancreas, and gastric mucosa. Additionally, it is specifically expressed in the proximal tubule of normal kidneys and in renal cell cancer. Thus , Cadherin-6 is a new prognostic factor for renal cancer.

          Human Cadherin-6/CDH6 cdna-clone References
        • Paul R, et al. (1997) Cadherin-6, a cell adhesion molecule specifically expressed in the proximal renal tubule and renal cell carcinoma. Cancer Res. 57(13): 2741-8.
        • Paul R, et al. (2004) Cadherin-6: a new prognostic marker for renal cell carcinoma. J Urol. 171(1): 97-101.
        • Taniguchi H, et al. (2006) Classic cadherins regulate tangential migration of precerebellar neurons in the caudal hindbrain. Development. 133(10): 1923-31.
        • Liu Q, et al. (2006) cadherin-6 message expression in the nervous system of developing zebrafish. Dev Dyn. 235(1): 272-8.
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