Text Size:AAA

cluster of differentiation 8 / CD8

What is cluster of differentiation 8 / CD8 ?

Cluster of differentiation 8 / CD8 , also known as Ly-2 or Leu-2, is a two chain and transmembrane glycoprotein which is expressed on the surface of circulating T-cells. Cluster of differentiation 8 serves as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the class I MHC protein. There are two isoforms of the protein, alpha and beta, each encoded by a different gene. Cluster of differentiation 8 exists as both a heterodimer and a homodimer

What is the role of cluster of differentiation 8 in the immune system?

Cluster of differentiation 8 was first discovered as a cell surface marker in mice and was used to distinguish between CD8+ Cytotoxic T lymphocytes (CTLs) and CD4+ Th cells. Cluster of differentiation 8 has been shown to be involved in CTL co-activation by increasing antigen sensitivity, and by stabilising the TCR/MHC interaction. In order to carry out these roles, the CD8 co-receptor binds to a distinct invariant region of the MHCI molecule, compared to the TCR, allowing the potential for tripartite (TCR/pMHC/CD8) complex formation.

Why is it important to study cluster of differentiation 8?

Cluster of differentiation 8 is often described as a T-cell co-receptor because it has important role in T-cell signalling, to induce TCR mediated T-cell activation signals. cluster of differentiation 8 co-receptor is also important for that stabilisation of the interface between CD8+ T-cells and target cells, and activation of intestinal epithelial T lymphocytes. Therefore, CD8 has been the target of many therapeutic strategies designed to modulate T-cell responses during auto-immune reactions, allergy and organ transplant rejection.

Cluster of differentiation 8 in HIV infection:

Cluster of differentiation 8 play a crucial role in controlling HIV replication during the early phase of infection. HIV-specific CD8 T-cells are targeted at the dominant viral variant and their emergence is associated with a rapid fall in viral load before the development of an antibody response. Cluster of differentiation 8 antiviral factor that inhibits HIV replication, and may or may not directly kill CD4 T-cells.

Cluster of differentiation antigen 8 /CD8 Reasearch Reagent Category

Cluster of differentiation antigen 8a/CD8a Proteins Cluster of differentiation antigen 8b/CD8b Proteins
Cluster of differentiation antigen 8a/CD8a Antibodies Cluster of differentiation antigen 8b/CD8b Antibodies
Cluster of differentiation antigen 8a/CD8a Genes Cluster of differentiation antigen 8b/CD8b Genes
Cluster of differentiation antigen 8a /CD8a other products Cluster of differentiation antigen 8b /CD8b other products

Cluster of differentiation 8: References

1. Hess C et al. HIV-1 specific CD8+ T-cells with an effector phenotype and control of viral replication. Lancet 363: 863-866, 2004
2. van Baarle et al. Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue. Trends Immunol 23 (12): 586-591, 2002
3. Boaz M et al. Presence of HIV-1 gag-specific IFN-gamma+ IL-2+ and CD28+ IL-2+ CD4 T cell responses is associated with non-progression in HIV-1 infection. J Immunol 169: 6376-6385, 2002
4. Shepard BD Early changes in T-cell activation predict antiretroviral success in salvage therapy of HIV infection. J Acquir Immune Defic Syndr 48(2):149-155, 2008
5. Giorgi JV et al. Shorter survival in advanced HIV type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J Infect Dis 179: 859-870, 1999
6. O'Brien TR et al. Effect of chemokine receptor gene polymorphisms on the response to potent antiretroviral therapy. AIDS 14: 821-826, 2000
7. Leahy DJ, Axel R, Hendrickson WA. Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution. Cell 68 (6): 1145–62, 1992
8. Gao G, Jakobsen B. Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor. Immunol Today 21 (12): 630–6, 2000
9. CD8 alpha - Marker for cytotoxic T Lymphocytes. Retrieved 11 January 2016.