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CIB1  Protein, Antibody, ELISA Kit, cDNA Clone

CIB1 Related Area

CIB1 Related Pathways

CIB1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

CIB1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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CIB1 Summary & Protein Information

CIB1 Background

Subunit structure: Monomer. Interacts with MYO1C. Interacts (via C-terminal region) with PPP3R1 and CACNA1C; the interactions increase upon cardiomyocytes hypertrophy (By similarity). Interacts with the heterodimeric integrin alpha-IIb/beta3 (ITGA2B-ITGB3). Interacts with ITGA2B (via cytoplasmic domain); the interaction is direct and calcium-dependent. Interacts with the protein kinases PLK2/SNK and PRKDC (via the region immediately upstream of the kinase domain). Interacts with PLK3; the interaction inhibits PLK3 kinase activity. Interacts with PSEN2. Interacts (via C-terminus) with F8. Interacts with NBR1 (via C-terminus). Interacts with FEZ1 (via C-terminus). Interacts with UBR5 (via C-terminus); the interaction is sensitive to DNA damage, and may target CIB1 for ubiquitin-mediated degradation. Interacts with IFI6. Interacts with BCL2. Interacts with ITPR3; the interaction occurs in a calcium-dependent manner. Interacts with PTK2/FAK1. Interacts with MAP3K5; the interaction inhibits MAP3K5 activation by phosphorylation, and its subsequent interaction with TRAF2. Isoform 2 interacts with PRKD2 (via N-terminal AP-rich region), PTK2/FAK1 and PAK1. Interacts with TAS1R2 (via C-terminus); the interaction is independent of the myristoylation state of CIB1. Interacts (via C-terminal region) with STMN2 (via the N-terminal region); the interaction is direct, occurs in a calcium-dependent manner and attenuates the STMN2-induced neurite outgrowth inhibition. Interacts with SPHK1, the interaction occurs in a calcium-dependent manner. Interacts with ITGA2B (via C-terminal cytoplasmic tail); the interaction occurs upon platelet aggregation and is stabilized/increased in a calcium and magnesium-dependent manner. Interacts with PAK1 (via N-terminal region); the interaction is direct and occurs in a calcium-dependent manner. Interacts with RAC3 (via C-terminal region); the interaction induces their association with the cytoskeleton upon alpha-IIb/beta3 integrin-mediated adhesion. Interacts with ITGA5 and ITGAV. {ECO:0000250, ECO:0000269|PubMed:10366599, ECO:0000269|PubMed:10477286, ECO:0000269|PubMed:11323029, ECO:0000269|PubMed:11756406, ECO:0000269|PubMed:11856312, ECO:0000269|PubMed:12011095, ECO:0000269|PubMed:12023286, ECO:0000269|PubMed:12881299, ECO:0000269|PubMed:14992593, ECO:0000269|PubMed:15475008, ECO:0000269|PubMed:15574431, ECO:0000269|PubMed:15685448, ECO:0000269|PubMed:15883187, ECO:0000269|PubMed:15933764, ECO:0000269|PubMed:16061695, ECO:0000269|PubMed:16418530, ECO:0000269|PubMed:16723353, ECO:0000269|PubMed:18627437, ECO:0000269|PubMed:19388079, ECO:0000269|PubMed:19805025, ECO:0000269|PubMed:19854831, ECO:0000269|PubMed:20473878, ECO:0000269|PubMed:20951827, ECO:0000269|PubMed:21215777, ECO:0000269|PubMed:21264284, ECO:0000269|PubMed:21388953, ECO:0000269|PubMed:22283712, ECO:0000269|PubMed:22779914, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:24011356, ECO:0000269|PubMed:9030514, ECO:0000269|PubMed:9372844}.
Domain: The EF-hands may also bind magnesium ions in the presence of high Mg(2+) levels and low Ca(2+) levels.
Subcellular location: Membrane; Lipid-anchor. Cell membrane, sarcolemma. Cell membrane. Apical cell membrane. Cell projection, ruffle membrane. Cell projection, filopodium tip. Cell projection, growth cone. Cell projection, lamellipodium. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Nucleus. Note=Colocalized with PPP3R1 at the cell membrane of cardiomyocytes in the hypertrophic heart (By similarity). Colocalized with NBR1 to the perinuclear region. Colocalizes with TAS1R2 in apical regions of taste receptor cells. Colocalized with RAC3 in the perinuclear area and at the cell periphery. Colocalized with PAK1 within membrane ruffles during cell spreading upon readhesion to fibronectin. Redistributed to the cytoskeleton upon platelet aggregation. Translocates from the cytosol to the plasma membrane in a calcium-dependent manner. Colocalized with STMN2 in the cell body, neurites and growth cones of neurons. Colocalized with STMN2 to the leading edge of lamellipodia. Colocalized with PLK3 at centrosomes in ductal breast carcinoma cells. {ECO:0000250}.; Isoform 2: Cytoplasm, perinuclear region {ECO:0000269|PubMed:23503467}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:23503467}.
Tissue specificity: Detected in platelets and in cell lines of megakaryocytic and erythrocytic lineages. Both isoform 1 and isoform 2 are detected in various cancer cell lines, with isoform 2 being the predominant form (at protein level). Ubiquitously expressed. {ECO:0000269|PubMed:10477286, ECO:0000269|PubMed:11856312, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:9030514, ECO:0000269|PubMed:9372844}.
Induction: Up-regulated during breast cancer progression.
Post-translational: Phosphorylation of isoform 2 at Ser-78 by PRKD2 increases its ability to stimulate tumor angiogenesis. {ECO:0000305|PubMed:23503467}.
Sequence similarity: Contains 2 EF-hand domains. {ECO:0000255|PROSITE-ProRule:PRU00448}.
General information above from UniProt

CIB1 Alternative Name

CIB,CIBP,PRKDCIP,SIP2-28,KIP1, [homo-sapiens]
Kip,Cibkip,Prkdcip, [mus-musculus]

CIB1 Related Studies