CD30 / TNFRSF8 Protein

CD30 / TNFRSF8 Protein Overview

CD30 / TNFRSF8 protein name

Recommended name
Tumor necrosis factor receptor superfamily member 8
Aliases
KI-1
Alternative name
CD30L receptor Ki-1 antigen Lymphocyte activation antigen CD30 CD_antigen: CD30

CD30 / TNFRSF8 Gene family protein

CD30 / TNFRSF8 Protein Sequence

Species Human CD30 / TNFRSF8 protein
Length 595
Mass (Da) 63747
Sequence Human CD30 / TNFRSF8 protein sequence
Species Mouse CD30 / TNFRSF8 protein
Length 498
Mass (Da) 53216
Sequence Mouse CD30 / TNFRSF8 protein sequence
Species Rat CD30 / TNFRSF8 protein
Length 493
Mass (Da) 52658
Sequence Rat CD30 / TNFRSF8 protein sequence

CD30 / TNFRSF8 Protein Molecular Weight & PI

Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Ki-1 antigen) (Lymphocyte activation antigen CD30) (CD30 antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 19-595 Tumor necrosis factor receptor

Molecular weight (Da)

61866.81

Theoretical pI

5.32

CD30 / TNFRSF8 Protein Structure

STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A HUMAN CD30 PEPTIDE
Deposited
1999-09-07   Released:  2003-12-02
Deposition Author(s)
Ye, H., Park, Y.C., Kreishman, M., Kieff, E., Wu, H.
Organism(s)
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.0000 Å
R-Value Free
0.244
R-Value Work
0.220
1D01 From PDB

CD30 / TNFRSF8 Protein Interaction

Recombinant CD30 / TNFRSF8 Protein Feature

CD30 / TNFRSF8 Protein, Human, Recombinant (His Tag)

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
1. Measured by its binding ability in a functional ELISA. 2. Immobilized recombinant human CD30 at 2 μg/ml (100 μl/well) can bind human CD30L Fc Chimera with a linear range of 6.4-800 ng/ml.

Recombinant CD30 / TNFRSF8 protein citations

Title
Highly potent, anthracycline-based antibody drug conjugates generated by enzymatic, site-specific conjugation
Year
2017
Author
Stefan, N;Gébleux, R;Waldmeier, L;Hell, T;Escher, M;Wolter, FI;Grawunder, U;Beerli, RR;
Journal
Mol. Cancer Ther

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