CD antigens related to immunotherapy

CD antigens are widely used for immunophenotyping. CD antigens are a series of surface proteins on leukocytes that serve to differentiate the many types of white blood cells. CD proteins serve as receptors and ligands such as CD4 and CD8 on T lymphocytes which serve to regulate the adaptive immune response. Some CD proteins regulate cell signaling, while others ensure cell adhesion which is an important aspect of adaptive immunity.

This is very confusing and is one reason why hematopathologists keep lots of aspirin in their desks. Nonetheless, if you study lymphomas, you will have to know at least the basics of this scheme. Here are the basics:

All lymphoid cells are reactive for CD45.
Almost all of B-cells are reactive for CD19, CD20 and CD22. Certain low-grade B-cell lymphomas are reactive for two markers otherwise usually found on T-cells: CD5 and CD43. Follicular center cell lymphomas (as well as very different fish, lymphoblastic lymphomas) are frequently CD10(+).
Pan T-cell markers (present on almost all T-cells) include CD2, CD3, CD5, and CD7. Most T-cells mark with either CD4 (helper cells) or CD8 (suppressor cells or cytotoxic cells).
NK cells are frequently associated with CD16, CD56, or CD57.

CD antigens chart related to immunotherapy

Name Alias Function
CD2 T11, LFA-2, SRBC-R, Erythrocyte receptor, LFA-3R Adhesion between T-cells and other cell types and T-cell activation.
CD3d T3D, IMD19, CD3-DELTA T-cell activation signaling and regulation of TCR expression
CD34 T3E, TCRE,CD3 epsilon T-cell activation signaling and regulation of TCR expression
CD3G T3G, IMD17, CD3-GAMMA T-cell activation signaling and regulation of TCR expression
CD18 Integrin β2, ITGB2, MFI7 Adhesion, cell signaling
CD19 B4, Leu-12 Regulates B-cell development, activation and differentiation. Signal transduction
CD20 B1, Bp35, MS4A1 B-cell activation and proliferation
CD22 BL-CAM, Siglec-2, Leu-14 B-cell adhesion and signal transduction
CD25 Tac, p55, IL2RA Receptor for IL2
CD30 Ki-1, TNFRSF8 Regulates lymphocyte proliferation and cell death. Activation of NF-κB
CD32b FcγRII, FCGR2B,Fc gamma RIIB Phagocytosis of immune complexes and regulation of antibody production
CD33 p67, Siglec-3 Cell adhesion, cell-cell signaling, inhibitory receptor, and apoptosis
CD40 TNFRSF5 Cell adhesion, cell proliferation, and signal transduction
CD52 CAMPATH-1, HE5, CDW52 Complement-mediated cell lysis and antibody-mediated cellular cytotoxicity
CD58 LFA-3 APC-T-cell adhesion. Killer target cell interaction.
CD66e CEA, CEACAM5 Homophilic and heterophilic adhesion. May play a role in the metastasis of cancer cells
CD80 B7, B7-1, BB1 Costimulation of T-cell activation and proliferation.
CD86 B70, B7-2, CD28LG2 Costimulation of T-cell activation and proliferation.
CD106 VCAM-1, L1CAM Leukocyte adhesion. Transmigration and costimulation of T-cells.
CD120b TNFR-II, TNFRSF1B, TNFR2 Receptor for TNF. Involved in cell differentiation, apoptosis and necrosis
CD126 IL-6R, IL6R, gp80 Receptor for IL6
CD134 OX-40, TNFRSF4 T-cell activation, proliferation and differentiation, apoptosis and cell adhesion
CD137 TNFRSF9, 4-1BB, CDw137, ILA Costimulation of T-cell activation. Regulates T-cell-dependent immune responses.
CD152 CTLA-4 T-cell inhibition
CD154 CD40L, CD40 Ligand, gp39, TRAP Mediates B-cell proliferation, IgE production and is involved in immunoglobulin class switching
CD221 IGF-1 R, IGF1R Receptor for IGF-I and IGF-II. Mediates mitogenic and anti-apoptotic signals
CD227 MUC1, EMA, PUM, Mucin 1 Cell adhesion and signaling
CD254 TNFSF11, RANKL, OPGL, ODF Involved in dendritic cell maturation
CD257 BLyS, BAFF, TALL-1, TNFSF13B Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity
CD261 TRAIL-R1, DR4, TNFRSF10A Induces apoptosis, promotes activation of NFkB
CD262 TRAIL-R2, DR5, TNFRSF10B Activated by TNFSF10 / TRAIL and transduces apoptosis signal
CD279 PD1, SLEB2 Inhibitory cell surface receptor involved in T-cell tolerance
CD309 VEGFR2, KDR, FLK-1 Activation of this receptor by VEGF plays a role in angiogenesis, development, wound healing, cell proliferation, migration and differentiation
CD326 Ep-CAM, Ly74, EGP314, TROP-1, TACSTD1 A homotypic calcium-independent T-cell adhesion molecule
CD340 ERBB2, MLN 19 Binds tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways