Quick Order

CD antigens / Cluster of differentiation

 The CD antigens / Cluster of differentiation nomenclature was established in the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA), which was held in Paris in 1982. Today, the HLDA Workshop meeting has been held 10 times and has over 371 CD antigens molecule have been identified. CD antigens for cluster of differentiation, which indicates a defined subset of cellular surface receptors (epitopes) that identify cell type and stage of differentiation, and which are recognized by antibodies. The CD antigens are protocol used for the identification and investigation of cell surface molecules providing targets for immunophenotyping of cells. CD antigens can act in lot of ways, like as recepters or ligands in terms of physiology. As a siganl, CD antigens usually initiated, altering the behavior of the cell. Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD antigens are used widely for research, immunotherary, tumor and drug target.

CD antigens chart

CD 1-50   CD 51-100   CD 101-150   CD 151-200   CD 201-250   CD 251-300   CD 301-
                       
CD 1-50                        
Name Alias Function
CD1b antigens T6 Antigen presenting protein
CD1c antigens R7, CD1, CD1A, BDCA1 Non peptide antigen presentation to T-cell receptors on NKT cells.
CD1d antigens R3G1 Antigen presenting protein
CD2 antigens T11, LFA-2, SRBC-R, Erythrocyte receptor, LFA-3R Adhesion between T-cells and other cell types and T-cell activation.
CD3d antigens T3D, IMD19, CD3-DELTA T-cell activation signaling and regulation of TCR expression
CD3e antigens T3E, TCRE,CD3 epsilon T-cell activation signaling and regulation of TCR expression
CD3G antigens T3G, IMD17, CD3-GAMMA T-cell activation signaling and regulation of TCR expression
CD4 antigens T4 T-cell activation, thymic differentiation and receptor for HIV
CD5 antigens T1, Tp67, LEU1 Regulates T-cell receptor signaling
CD6 antigens T12, OX52, TP120 T-cell activation and cell adhesion
CD7 antigens LEU 9, GP40, TP41 T-cell interactions
CD8a antigens T8, Leu-2, MAL,CD8 alpha Co-receptor for MHC class 1 molecules
CD8b antigens CD8B1,P37 Co-receptor for MHC class 1 molecules
CD9 antigens p24, MRP-1, 5H9 antigen, MIC3, TSPAN29, GIG2 Platelet activation and aggregation, and cell adhesion and cell motility
CD10 antigens CALLA, NEP, gp100, Neprilysin, SFE, MME, EPN Peptidase, regulates B-cell growth
CD11a antigens LFA-1, LFA1A, ITGAL Intracellular adhesion and costimulation.
CD11b antigens ITGAM, CR3A, MO1A, MAC-1, MAC1A, SLEB6 Cell adhesion, and immune response
CD11c antigens p150, 95, CR4, integrin αX, LFA-1A, ITGAX Cell adhesion
CD13 antigens Aminopeptidase N, APN, ANPEP,PEPN Aminopeptidase
CD14 antigens LPS-R Receptor for complex of LPS and LBP
CD15 antigens LeX, FUT4, ELFT, FCT3A, FUTIV, SSEA-1, FUC-TIV
CD15 mediates phagocytosis and chemotaxis, found on neutrophils; expressed in patients with Hodgkin disease, some B-cell chronic lymphocytic leukemias, acute lymphoblastic leukemias, and most acute nonlymphocytic leukemias
CD16a antigens FcγRIIIA, FCGR3A, FCG3, FCGR3, IGFR3 Low affinity Fc receptor. Mediates phagocytosis and antibody-dependent T-cell-mediated cytotoxicity
CD16b antigens FcγRIIIB, FCGR3B, FCG3, FCGR3, IGFR3 Low affinity Fc receptor
CD18 antigens Integrin β2, ITGB2, MFI7 Adhesion, cell signaling
CD19 antigens B4, Leu-12 Regulates B-cell development, activation and differentiation. Signal transduction
CD20 antigens B1, Bp35, MS4A1 B-cell activation and proliferation
CD21 antigens C3DR, CR2, EBV-R Signal transduction. Regulator of complement activation
CD22 antigens BL-CAM, Siglec-2, Leu-14 B-cell adhesion and signal transduction
CD23 antigens FcεRII, BLAST-2, FCER2, CLEC4J Low affinity receptor for IgE, ligand for CD19, CD21 and CD81. Key molecule for B-cell activation and growth
CD24 antigens BA-1, Nectadrin Regulation of B-cell proliferation and differentiation
CD25 antigens Tac, p55, IL2RA Receptor for IL2
CD26 antigens DPP IV, DPP4, ADABP, ADCP2 Exoprotease. HIV pathogenesis
CD27 antigens T14, TNFRSF 7, CD27L receptor Costimulation of B- and T-cell activation
CD28 antigens TP44, T44 T-cell proliferation, survival, IL-2 production, and Th2 cell development
CD29 antigens Integrin β1, ITGB1, FNRB Lymphocyte and endothelial adhesion, lymphocyte trafficking and transvascular migration.
CD39 antigens Integrin β1, ITGB1, FNRB Lymphocyte and endothelial adhesion, lymphocyte trafficking and transvascular migration
CD30 antigens Ki-1, TNFRSF8 Regulates lymphocyte proliferation and cell death. Activation of NF-κB
CD31 antigens PECAM-1 Cell adhesion. Plays a key role in leukocyte trafficking across endothelium
CD32 antigens FCG2, FCGR2A1, FCGR2 Regulation of B-cell function. Induces phagocytosis and mediator release.
CD32a antigens FcγRII, FCGR2A,Fc gamma RIIA Innate and adaptive immune responses
CD32b antigens FcγRII, FCGR2B,Fc gamma RIIB Phagocytosis of immune complexes and regulation of antibody production
CD33 antigens p67, Siglec-3 Cell adhesion, cell-cell signaling, inhibitory receptor, and apoptosis
CD34 antigens   Cell adhesion
CD35 antigens CR1, C3b/C4b receptor Receptor for complement components C3b and C4b. Mediates adhesion and phagocytosis
CD36 antigens GPIV, GP3B, GP4, SCARB3 Cell adhesion, cholesterol transport, scavenger receptor
CD37 antigens TSPAN26,GP52-40 Signal transduction. Regulates T-cell proliferation
CD38 antigens T10, ADPRC1,ADP ribosyl cyclase 1 Cell adhesion and signal transduction
CD39 antigens NTPDase 1, ENTPD1 B-cell adhesion. Protects activated cells from lysis
CD40 antigens TNFRSF5 Cell adhesion, cell proliferation, and signal transduction
CD41 antigens ITGA2B Platelet activation and aggregation.
CD42b antigens GP1BA, BSS, GP1B, VWDP, BDPLT3 Cell adhesion, cell activation
CD42c antigens GPIbb,GPIBB Platelet adhesion and aggregation
CD43 antigens Leukosialin, sialophorin, SPN Cell adhesion and T cell activation
CD44 antigens H-CAM, Pgp-1, Epican, HUTCH-I, LHR, ECMR-III Cell adhesion and migration
CD45 antigens LCA, T200, B220, PTPRC Critical for B- and T-cell receptor mediated activation. Regullar of cell growth and differentiation
CD46 antigens MCP, TLX Inhibitory complement activation
CD47 antigens IAP, MER6 Cell adhesion and signal transduction
CD48 antigens Blast-1, BCM1 Cell adhesion and T-cell costimulation
CD49b antigens VLA-2, ITGA2 Adhesion and platelet aggregation.
CD49c antigens VLA-3, ITGA3 Adhesion and signal transduction
CD49e antigens VLA-5, ITGA5 Adhesion, regulation of cell survival and apoptosis
CD49f antigens VLA-6, ITGA6 Embryogenesis, adhesion and cell migration
CD50 antigens ICAM-3 Adhesion and costimulation
Back to top
Name Alias Function
CD51 antigens Vitronectin receptor, ITGAV, MSK8 Adhesion and signal transduction
CD52 antigens CAMPATH-1, HE5, CDW52 Complement-mediated cell lysis and antibody-mediated cellular cytotoxicity
CD53 antigens Tetraspanin-25, MOX44 Signal transduction. Cell adhesion, activation, and migration
CD54 antigens ICAM-1 Cell adhesion, lymphocyte activation, and migration
CD55 antigens DAF Regulates complement activation. Signal transduction
CD56 antigens NCAM1 Homophilic and heterophilic adhesion
CD57 antigens B3GAT1, GLCATP, GLCUATP, HNK1, LEU7, NK-1, NK1 Adhesion molecule.
CD58 antigens LFA-3 APC-T-cell adhesion. Killer target cell interaction.
CD59 antigens Protectin, MAC- inhibitor Prevents complement polymerization. Protects cells from complement mediated lysis
CD59a antigens    
CD59b antigens    
CD61 antigens GPIIIa, ITGB3, GP3A Cell adhesion
CD62E antigens E-selectin, ELAM-1, SELE Tumor cell adhesion and angiogenesis
CD62L antigens L-selectin, LECAM-1, SELL Leukocyte rolling and homing on activated endothelium
CD62P antigens P-selectin, PADGEM, SELP, LECAM3 Cell adhesion
CD63 antigens LIMP, LAMP-3, MLA1 Cell growth and motility regulation; complexes with integrins
CD64 antigens FcγRI, FCGR1, FCGR1A Innate and adaptive immune responses
CD66a antigens BGP-1, NCA-160, CEACAM1 Neutrophil activation, homophilic and heterophilic adhesion
CD66b antigens CD67, CGM6, CEACAM8 Cell adhesion and neutrophil activation
CD66c antigens NCA, CEACAM6
Cell adhesion and neutrophil activation
CD66d antigens CGM1, CEACAM3 Cell adhesion and neutrophil activation
CD66e antigens CEA, CEACAM5 Homophilic and heterophilic adhesion. May play a role in the metastasis of cancer cells
CD66f antigens PSG1, Sp-1, PSBG1 Cell adhesion, cellular migration, pathogen binding and activation of signaling pathways
CD68 antigens Macrosialin, gp110, KP1 Macrophage homing
CD69 antigens AIM, CLEC2C, EA1 Signal transmission in NK cells and platelets
CD70 antigens Ki-24, CD27L, TNFSF7 Induces proliferation of costimulated T-cells. Enhances the generation of cytotoxic T-cells and contributes to T-cell activation.
CD71 antigens T9, TFRC Controls iron uptake during cell proliferation
CD72 antigens Lyb-2, Ly-19, Ly-32 B-cell activation and proliferation
CD73 antigens 5'-nucleotidase, NT5E Nucleotidase
CD74 antigens LN2, Ii, DHLAG MHC class II antigen processing
CD75 antigens ST6GAL1, Sialyltransferase 1 Functional maturation of B lymphocytes
CD77 antigens Gb3, Pk blood group, BLA, A4GALT Induces apoptosis
CD79a antigens MB1, IGA, Ig-alpha Subunit of B-cell antigen receptor.Signal transduction
CD79b antigens B29, IGB, Ig-beta Subunit of B-cell antigen receptor.Signal transduction
CD80 antigens B7, B7-1, BB1 Costimulation of T-cell activation and proliferation.
CD81 antigens TAPA-1, Tetraspanin-28 Signal transduction and Cell adhesion
CD82 antigens R2, KAI1, Tetraspanin-27 Signal transduction
CD83 antigens HB15 Antigen presentation and immune stimulation
CD84 antigens SLAM5 Homophilic adhesion molecule. Enhances T-cell activation and cytokine production
CD85a antigens LILRB3, ILT5, LIR3 Immune regulation
CD85c antigens LILRB5, LIR8 Immune regulation
CD85d antigens LILRB2, ILT4, LIR2, MIR10 Down regulates the immune response and involved in the development of tolerance
CD85e antigens LILRA3, ILT6, LIR4 May be involved in triggering innate immune responses
CD85f antigens LILRA5, ILT11, LIR9 May be involved in triggering innate immune responses
CD85i antigens LILRA1, LIR6 May be involved in triggering innate immune responses
CD85j antigens LILRB1, ILT2, LIR1 Inhibits cytotoxicity in NK and T cells upon ligand binding
CD86 antigens B70, B7-2, CD28LG2 Costimulation of T-cell activation and proliferation
CD87 antigens UPA-R, PLAUR, MO3 Cell chemotaxis and adhesion
CD88 antigens C5A, C5AR, C5R1, C5AR1 Cell activation
CD89 antigens FcαR, FCAR IgA Fc receptor
CD90 antigens Thy-1 Costimulation of lymphocytes and cell adhesion
CD91 antigens LRP1,A2MR,APOER Endocytic receptor involved in intracellular signaling, lipid homeostasis, and phagocytosis of apoptotic cells
CD93 antigens C1qR, C1QR1, MXRA4 Cell adhesion and clearance of apoptotic cells
CD94 antigens KLRD1 Inhibits NK function
CD95 antigens Apo-1, FASLG, APTL, TNFRSF6 Induces apoptosis
CD96 antigens TACTILE Involved in adhesive interactions of activated T cells and NK cells
CD97 antigens ADGRE5 Neutrophil migration, cell adhesion and signaling
CD98 antigens 4F2hc, SLC3A2, MDU1 Cell activation and cell aggregation
CD99 antigens MIC2, E2 Leukocyte migration, T-cell activation and cell adhesion
CD100 antigens Semaphorin 4D, SEMA4D Enhancement of B-cell and dendritic cell responses
Back to top
Name Alias Function
CD102 antigens ICAM-2 Adhesion, costimulation and lymphocyte recirculation
CD103 antigens HUMINAE, ITGA1 Lymphocyte retention. Receptor for E-cadherin.
CD104 antigens ITGB4, GP150 Cell adhesion, and immune response
CD105 antigens Endoglin, ENG, END Angiogenesis. Regulatory component of TGF-beta receptor complex.Modulates cellular response to TGF beta 1
CD106 antigens VCAM-1, L1CAM Leukocyte adhesion. Transmigration and costimulation of T-cells.
CD107a antigens LAMP-1 Cell adhesion
CD107b antigens LAMP-2 May be involved in leukocyte adhesion.Implicated in tumor cell metastasis
CD108 antigens Semaphorin 7A, SEMA7A Monocyte activator. Negative regulator of T-cell responses. Stimulates axon growth and guidance during development
CD111 antigens PVRL1, PRR1, Nectin-1, HVEC Entry mediator for several herpes viruses (HSV1, HSV2, PRV, BHV1).Believed to be involved in cell adhesion mechanisms
CD112 antigens PVRL2, PRR2, Nectin-2, HVEB Intracellular adhesion, component of adherins junctions. Receptor for herpes simplex virus
CD113 antigens PVRL3, Nectin-3 Adhesion molecule that interacts with afadin
CD114 antigens GCSFR, CSF3R Myeloid cell proliferation and differentiation
CD115 antigens M-CSFR, c-fms, CSF1R Monocytic cell proliferation and differentiation
CD116 antigens GM-CSFRα, CSF2RA, GM-CSFR Myeloid cell hematopoiesis and differentiation
CD117 antigens c-kit, SCFR, KIT Crucial for development of gonadal and pigment stem cells
CD118 antigens LIFR, gp190 Regulates a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion
CD119 antigens IFNγR, IFNGR1 Receptor for interferon gamma, a multifunctional immunomodulator
CD120a antigens TNFR-I, TNFRSF1A, TNFR1 Receptor for TNF
CD120b antigens TNFR-II, TNFRSF1B, TNFR2 Receptor for TNF. Involved in cell differentiation, apoptosis and necrosis
CD121a antigens IL-1R type I, IL1R1, IL1R1, IL-1 RI Receptor for IL1A, IL1B and IL1RN. Mediates IL1 signaling
CD121b antigens IL-1R, type II, IL1R2, IL-1R2
Receptor for IL1A, IL1B and IL1RN. Mediates IL1 signaling
CD122 antigens IL-2Rβ, IL-2RB Receptor for IL2 and IL15
CD123 antigens IL-3R, IL3RA Receptor for IL3
CD124 antigens IL4RA, IL4R Receptor for IL4 and IL13
CD125 antigens IL5RA, IL5R Receptor for IL5
CD126 antigens IL-6R, IL6R, gp80 Receptor for IL6
CD127 antigens IL-7R, IL7R Receptor for IL7
CD130 antigens IL-6Rβ, gp130, IL6ST Transmits activities of IL6, IL11, LIF and CNF
CD131 antigens IL-3R common β, IL3RB, CSF2RB, IL5RB Component of the high affinity IL3, GM-CSF and IL5 receptors
CD132 antigens IL2RG, Common γ Forms complexes with other cell surface proteins including CD25, CD122, CD124, CD127 and others. Complexes with other cell surface proteins to form receptors for the cytokines IL2, IL4, IL7, IL9, and IL15.
CD133 antigens PROM1, RP41, CORD12, PROML1, MSTP061 CD133 has been proposed to act as an organizer of cell membrane topology.
CD134 antigens OX-40, TNFRSF4 T-cell activation, proliferation and differentiation, apoptosis and cell adhesion
CD135 antigens Flt3, Flk2 Receptor for MSP which regulates cell adhesion, motility, growth, and survival.
CD136 antigens MSP-R, RON, PTK8, MST1R Receptor for MSP which regulates cell adhesion, motility, growth, and survival.
CD137 antigens TNFRSF9, 4-1BB, CDw137, ILA Costimulation of T-cell activation. Regulates T-cell-dependent immune responses.
CD137L antigens 4-1BB, TNFRSF9, ILA Costimulation of T-cell activation
CD138 antigens Syndecan-1, SDC Cell proliferation, cell migration, and cell-matrix interactions
CD140a antigens PDGFRα, PDGFRA Cell proliferation, differentiation and survival
CD140b antigens PDGFRβ, PDGFRB Cell proliferation, differentiation and survival
CD141 antigens THBD, AHUS6, BDCA3, THPH12, THRM, TM Activation of protein C and initiation of protein C anti-coagulant pathway.
CD142 antigens Tissue Factor, F3 Initiates blood clotting
CD143 antigens ACE1, DCP, DCP1, ICH, MVCD3 Converts angiotensin I to angiotensin II by release of terminal His-Leu, which results in an increase of the vasoconstrictor activity of angiotensin. Cell adhesion.
CD144 antigens VE-Cadherin, Cadherin-5 Cell adhesion.
CD146 antigens MUC18, S-endo, MCAM Cell adhesion. Involved in heterophilic cell to cell interactions
CD147 antigens Neurothelin, basoglin, Basigin, BSG,EMMPRIN Cell adhesion and T-cell activation
CD148 antigens HPTP-eta, DEP1, PTPRJ Tyrosine phosphatase cell signaling, cell growth and differentiation, mitotic cycle and oncogenic transformation
CD150 antigens SLAM, SLAMF1, IPO-3 Costimulation of T-cells and B-cells
Back to top
Name Alias Function
CD151 antigens PETA-3, GP27, SFA-1, Cell adhesion.
CD152 antigens CTLA-4 T-cell inhibition
CD153 antigens CD30L, TNFSF8 Binds to CD30 and induces proliferation of T-cells
CD154 antigens CD40L, CD40 Ligand, gp39, TRAP Mediates B-cell proliferation, IgE production and is involved in immunoglobulin class switching
CD155 antigens PVR, NECL-5 Mediates NK cell adhesion and triggers their effector functions.
CD156a antigens ADAM8 Possible involvement in extravasation of leukocytes
CD156b antigens ADAM17, ADAM18, CSVP, NISBD, NISBD1, TACE Cleaves transmembrane form of TNF-α to generate the soluble active form.
CD156c antigens ADAM10 Metalloprotease activity, cleaves many proteins including TNF-α and E-cadherin
CD157 antigens BST-1 Synthesis of cyclic ADP-ribose and putative involvement in pre-B-cell growth
CD158a antigens p58.1, KIR2DL1 Inhibits the activity of NK cells
CD158b2 antigens NKAT-2, KIR2DL3 Inhibits the activity of NK cells
CD158d antigens KIR2DL4, KIR-103AS Inhibits the activity of NK cells
CD158e antigens KIR3DL1 Receptor on natural killer cells for HLA Bw4 allele. Inhibits the activity of natural killer cells thus preventing cell lysis.
CD158z antigens KIR3DL3 Inhibits the activity of NK cells
CD159a antigens NKG2A, KLRC1, NKG2 Negative regulation of NK cell activation
CD160 antigens BY55, NK1 Broad specificity receptor for MHC class I molecules
CD161 antigens NKR-P1A, KLRB1 Inhibits NK cell mediated cytotoxicity. Induces immature thymocyte proliferation
CD162 antigens PSGL-1, SELPLG Mediates rapid rolling of leukocytes over vascular surfaces during inflammation
CD163 antigens M130, MM130 Clearance and endocytosis of hemoglobin / haptoglobin complexes by macrophages.
CD164 antigens MGC-24, MUC-24
Facilitates the adhesion of CD34+ cells to the stroma and negatively regulates their proliferation
CD166 antigens ALCAM Mediates cell adhesion by binding to CD6 for intrathymic T-cell development
CD167a antigens DDR1, MCK10 Receptor tyrosine kinase involved in cell-cell interactions
CD167b antigens DDR2 Receptor tyrosine kinase involved in cell-cell interactions
CD170 antigens Siglec-5, CD33-like2, SIGLEC5, OB-BP2 Adhesion molecule mediating sialic-acid dependent binding to cells
CD171 antigens NCAM-L1, L1CAM Multidomain cell adhesion molecule required for normal neurohistogenesis
CD172a antigens SIRPα, SHPS-1, SIRPA Immunoglobulin-like cell surface receptor for CD47. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment.
CD172b antigens SIRPβ, SIRB1 Immunoglobulin-like cell surface receptor for CD47. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment.
CD172g antigens SIRPγ, SIRPB2 Immunoglobulin-like cell surface receptor that mediates cell-cell adhesion on binding with CD47
CD176 antigens Thomson Friedrenreich Ag, TRF1, TRF Potentially involved in cell adhesion
CD177 antigens NB1 glycoprotein, HNA-2a Major immunogenic molecule of neutrophil membrane
CD178 antigens FasL, CD95L, FASLG, Fas Ligand T-cell mediated cytotoxicity
CD179a antigens VPREB1, IGI, IGVPB, VPREB  
CD179b antigens IGLL1 Early B-cell differentiation.
CD180 antigens RP-105 Controls B-cell recognition and signaling of LPS. Leads to NFkB activation.
CD181 antigens CXCR1, C-C, CD128, CKR-1, IL8R1, IL8RA, CMKAR1, IL8RBA, CDw128a, C-C-CKR-1 CD181 is a member of the G-protein-coupled receptor family, and a receptor for interleukin 8 (IL8).
CD182 antigens IL-8, GRO-α, β, γ, GCP-2, NAP-2, ENA-78 CD182 is a member of the G-protein-coupled receptor family, and a receptor for interleukin 8 (IL8)
CD183 antigens CXCR3 T-cell chemotaxis, integrin activation, and adhesion
CD184 antigens CXCR4, FB22, HM89, LAP3, LCR1, NPYR CD184 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes.
CD185 antigens CXCR5, BLR1 Homing and cell movement
CD186 antigens CXCR6, BONZO, STRL33, TYMSTR B-cell development
CD191 antigens CCR1, MIP-1αR, RANTES-R Chemotaxis, adhesion
CD192 antigens CCR2, MCP-1-R Leukocyte chemotaxis and is an HIV co-receptor
CD193 antigens CCR3,CCL11, CCL7, CCL13, CCL5, HIV-1 CD193 is a receptor for C-C type chemokines.CD193 is also known to be an entry co-receptor for HIV-1.
CD194 antigens CCR4, CKR4, K5-5, CMKBR4, ChemR13 CD194 is a receptor for C-C type chemokines.
CD195 antigens CCR5, CKR5, CCCKR5, CMKBR5, IDDM22 The CD195 belongs to the beta chemokine receptors family of integral membrane proteins.
CD196 antigens CCR6, BN-1, CKR-L3, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22 Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and affects dendritic cell chemotaxis.
CD197 antigens CCR7, BLR2, EBI1, CDw197, CMKBR7 The protein encoded by this gene is a member of the G protein-coupled receptor family.
CD200 antigens OX-2, OX2 Down-regulatory signal for myeloid cell function, costimulates T-cell proliferation
Back to top
Name Alias Function
CD201 antigens EPC-R, PROCR Enhances protein C activation
CD202b antigens Tie2, Tek Signaling, migration and adhesion
CD204 antigens Macrophage scavenger-R, MSR1 Endocytosis of macromolecules including low density lipoproteins, host defense
CD205 antigens DEC-205, LY75 Phagocytosis, endocytosis
CD206 antigens MRC1, MMR, MRC1L1, CLEC13D, CLEC13DL Cell adhesion, cell-cell signalling
CD207 antigens Langerin Pathogen receptor and processing of antigen for presentation to T-cells
CD208 antigens DC-LAMP, LAMP3 Dendritic cell maturation marker, involved in cell proliferation
CD209 antigens DC-SIGN Mediates antigen endocytosis and degradation binds pathogenic antigens such as HIV1 gp120
CD210 antigens IL10RA; IL10R; CD210a; HIL-10R; IL-10R1 CD210 is tha receptor of IL-10.
CD212 antigens IL-12-R β1, IL12RB1 Forms part of the receptor complexes for IL12 and IL23
CD213a1 antigens IL-13-R α1, IL13RA1 Forms part of the receptor complexes for IL13 and IL4
CD213a2 antigens IL-13-R α2, IL13RA2 Forms part of the receptor complex for IL13.
CD215 antigens IL15RA Receptor for IL15.
CD217 antigens IL-17R, IL17RA Receptor for IL17A and IL17F
CD218a antigens IL-18Rα, IL-1Rrp, IL18R1 Forms part of the receptor complex for IL18
CD218b antigens IL-18Rβ, IL18RAP Forms part of the receptor complex for IL18
CD220 antigens Insulin-R, Insulin Receptor, IINSR Insulin receptor
CD221 antigens IGF-1 R, IGF1R Receptor for IGF-I and IGF-II. Mediates mitogenic and anti-apoptotic signals
CD223 antigens LAG-3 Involved in lymphocyte activation, negative regulation of T-cell activation
CD224 antigens GGT1 Catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors, which contributes to oxidative homeostasis.
CD225 antigens IFITM1, Leu-13, DSPA2a Cell adhesion, cell growth and migration. Relays antiproliferative and homotypic adhesion signals
CD226 antigens DNAM-1, PTA-1, TLiSA1
Intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells
CD227 antigens MUC1, EMA, PUM, Mucin 1 Cell adhesion and signaling
CD228 antigens Melanotransferrin, MFI2 Involved in cellular iron uptake
CD229 antigens Ly-9, LY9, SLAMF3 Adhesion between T-cells and accessory cells
CD230 antigens Prion protein, PRNP Oxidative stress homeostasis,cell survival, and signal transduction
CD231 antigens TALLA-1, A15, Tspan-7, Cell proliferation and motility
CD233 antigens Band 3, SLC4A1 Anion exchanger across the cytoplasmic membrane, binding site for cytoskeletal proteins, enzymes and hemoglobin
CD235a antigens Glycophorin A, GYPA Major erythrocyte intrinsic membrane protein. Minimizes erythrocyte aggregation, receptor for influenza virus, Plasmodium falciparum and Hepatitis A virus
CD236 antigens Glycophorin C/D, GYPC Glycophorin-C regulates the stability of red cells
CD238 antigens Kell, KEL, Blood Group Kell Zinc endopeptidase cleaving endothelin 3. Contains the Kell blood group antigens
CD239 antigens B-CAM, BCAM Laminin alpha-5 receptor
CD242 antigens ICAM-4 Ligand for the leukocyte adhesion protein LFA-1
CD244 antigens 2B4, NAIL NK cell activation, NK cell and T-cell interaction
CD247 antigens TCRz, CD3-ZEETA Couples antigen recognition to several intracellular signaling pathways
CD249 antigens Aminopeptidase AM, EAP, ENPEP Converts angiotensin II to angiotensin III.
Back to top
Name Alias Function
CD252 antigens OX40L, gp34 Ligand for receptor TNFRSF4. Co-stimulates T-cell proliferation and cytokine production
CD253 antigens TRAIL, Apo-2L, TL2, TNFSF10 Induces cell death by apoptosis
CD254 antigens TNFSF11, RANKL, OPGL, ODF Involved in dendritic cell maturation
CD256 antigens APRIL, TALL-2, TRDL-1, TNFSF13 Important for B cell development
CD257 antigens BLyS, BAFF, TALL-1, TNFSF13B Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity
CD258 antigens LIGHT, HVEM-L, TNFRSF14 Stimulates T-cell proliferation, receptor for Herpes simplex virus
CD261 antigens TRAIL-R1, DR4, TNFRSF10A Induces apoptosis, promotes activation of NFkB
CD262 antigens TRAIL-R2, DR5, TNFRSF10B Activated by TNFSF10 / TRAIL and transduces apoptosis signal
CD264 antigens DCR2, TRAIL-R4, TNFRSF10D Receptor for TRAIL, inhibits apoptosis
CD265 antigens RANK, TRANCE-R, ODFR, TNFRSF11A Receptor for TRANCE. Enhances T-cell growth and dendritic cell function, plays a role in lymph node organogenesis
CD266 antigens TWEAK-R, FGF-inducible 14, TNFRSF12A Receptor for TWEAK. Promotes angiogenesis and the proliferation of endothelial cells.
CD267 antigens TACI, TNFR SF13B, TNFRSF13B Receptor for CD256 and CD257, mediates activation of the transcription factors NFAT, AP1, and NFkB.
CD268 antigens BAFFR, TR13C,TNFRSF13C B-cell receptor for CD257. B-cell response
CD269 antigens BCMA, TNFRSF13B, TNFRSF17 Receptor for CD256 and CD257, activates NFkB and JNK.
CD270 antigens HveA, TR2, TNFRSF14 Receptor for CD258 and CD272.
CD271 antigens NGFR, p75 (NTR) Regulates neuronal growth, migration, differentiation and cell death during stem cells.
CD272 antigens BTLA Lymphocyte inhibitory receptor
CD273 antigens B7DC, PD-L2, PDCD1L2 Stimulatory on dendritic cells, inhibits T-cell activation upon engaging the PD1 receptor.
CD274 antigens B7-H1, PD-L1 Found on activated T cells, B cells, and myeloid cells, to modulate activation or inhibition
CD275 antigens B7-H2, ICOSL, B7-RP1, GL50
Ligand for CD278. Costimulatory signal for T-cell proliferation and cytokine secretion, induces B-cell proliferation and differentiation
CD276 antigens B7-H3 Enhances the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling
CD277 antigens BTN3A1, butyrophilin SF3 A1, BTF5 T-cell activation
CD278 antigens ICOS, AILIM Mediate cell-cell interactions, and effective help for antibody secretion by B-cells
CD279 antigens PD1, SLEB2 Inhibitory cell surface receptor involved in T-cell tolerance
CD281 antigens TLR1 Pathogen recognition and activation of innate immunity, regulates TLR2 function
CD282 antigens TLR2 Mediator of innate immunity against bacterial cell wall lipoproteins. Induces activation of NFkB
CD283 antigens TLR3 Mediator of innate immunity against viral infection, activated by dsDNA
CD284 antigens TLR4 Mediator to innate immunity against bacterial polysaccharides. Induces activation of NFkB and production of type I interferons
CD286 antigens TLR6 Receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins
CD292 antigens BMPR1A, ALK3, SKR5 Receptor for BMP-2 and BMP-4
CD294 antigens PTGDR2, DP2, DL1R, CRTH2, GPR44 Regulates immune and inflammatory response, induces Th2 cells, eosino and baso migration
CD295 antigens LeptinR, LEPR, OB-R, Leptin Receptor Receptor for leptin. Involved in the regulation of fat metabolism and required for normal lymphopoiesis
CD296 antigens ART1,ARTC1 Catalyzes the transfer of ADP-ribose from NAD+ to arginine residues in proteins
CD297 antigens ART4, dombrock blood group Plays a role in the metabolism of Dombrock blood group antigen
CD298 antigens ATP1B3, ATPB-3 Component of Na+-K+ pump on neuronal membranes.
CD299 antigens DC-SIGN-related, LSIGN, DC-SIGN2, CLEC4M, DC-SIGNR Pathogen-recognition receptor involved in peripheral immune surveillance in liver. Recognizes mannose N-linked oligosaccharides in HIV-1, HIV-2, human cytomegalovirus and human SARS coronavirus
CD300a antigens CMRF35H, IRC1, IRp60M, CLM-8 NK cell function; also suppresses the effects of eotaxin, IL-5 and GM-CSF on neutrophils; and inhibits Ig-E dependent
CD300b antigens CLM-7, IREM3, LMIR5, CMRF35-A2 Activating immune receptor by interaction with TYROBP
CD300c antigens CMRF35A, LIR, CLM-6 Regulates IFN-alpha and TNF-alpha secretion by plasmacytoid dendritic cells
CD300e antigens CMRF35L, CLM-2, CMRF35-A5 Prevents apoptosis, triggers the production of pro-inflammatory cytokines and upregulates the expression of cell surface co-stimulatory molecules
CD300f antigens CLM-1, IREM-1, LMIR3 Inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation
CD300g antigens CLM-9, TREM4 May mediate L-selectin-dependent lymphocyte rollings
Back to top
Name Alias Function
CD301 antigens MGL, HML, CLEC10A, MGL1 Cell adhesion, cell-cell signaling and cellular recognition through glycoprotein binding
CD302 antigens DCL1, BIMLEC Cell adhesion and migration
CD304 antigens BDCA4, neuropilin 1, CLEC4C, NRP1 Angiogensis, axon guidance, cell survival, migration, and invasion
CD305 antigens LAIR1 Negative regulator of NK, B, and T cells
CD306 antigens LAIR2 Inhibits cellular activation and inflammation
CD307 antigens IRTA2, FCRL5 May function in B-cells activation and differentiation
CD307a antigens FCRL1 May function in B-cells activation and differentiation.
CD307b antigens FCRL2 May function in B-cells activation and differentiation.
CD309 antigens VEGFR2, KDR, FLK-1 Activation of this receptor by VEGF plays a role in angiogenesis, development, wound healing, cell proliferation, migration and differentiation
CD312 antigens ADGRE2, VBU, EMR2 Involved in immune and inflammatory response
CD314 antigens NKG2D, KLRK1 Receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells
CD315 antigens PTGFRN, CD9P-1, EWI-F, FPRP, SMAP-6 Inhibits binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor.
CD316 antigens EWI2, PGRL, CD81P3, KASP,IGSF8, EWI-2, KCT-4 Negative regulator of cell motility.
CD317 antigens BST2, HM1.24 IFN-induced antiviral host restriction factor
CD318 antigens CDCP1, SIMA135 Cell differentiation, homing and dissemination. May also have a pro-survival role
CD319 antigens CRACC, SLAMF7 Mediates NK cell activation and may play a role in lymphocyte adhesion
CD320 antigens FDC-SM-8D6, TCbIR, 8D6 antigen Augments the proliferation of plasma cell precursors generated by IL10. Receptor for the cellular uptake of transcobalamin bound cobalamin
CD321 antigens JAM-A, JAM-1, PAM-1, F11R Plays a role in epithelial tight junction formation, regulation of leukocyte erythrocytes. migration, epithelial barrier maintenance and platelet activation
CD322 antigens JAM-B, JAM-2, VE-JAM May play a role in lymphocyte homing to secondary lymphoid organs
CD324 antigens E-Cadherin, Uvomorulin, CDH1, E-cad Calcium-dependent cell adhesion protein
CD325 antigens N-Cadherin, NCAD, CDH2
In hippocampal cells, pancreatic cells and hepatocytes
CD326 antigens Ep-CAM, Ly74,, EGP314, TROP-1, TACSTD1 A homotypic calcium-independent T-cell adhesion molecule
CD327 antigens SIGLEC6, OB-BP1 Adhesion molecule that mediates sialic-acid dependent binding to cells
CD331 antigens FGFR1, Fms-like tyrosine kinase-2, KAL2, N-SAM Receptor for basic fibroblast growth factor.
CD332 antigens FGFR2, BEK, KGFR Cell-surface receptor for fibroblast growth factors
CD333 antigens FGFR3, ACH, CEK2 Cell-surface receptor for fibroblast growth factors
CD334 antigens FGFR4, JTK2, TKF Cell-surface receptor for fibroblast growth factors
CD335 antigens NCR1, LY94, NKP46, NK-p46 NK cell activation
CD336 antigens NKp44, Ly-95 homolog, NCR2 Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated NK cells to mediate tumor cell lysis
CD337 antigens NKp30, Ly117, NCR3 Cytotoxicity-activating receptor that contributes to the increased efficiency ofactivated NK cells to mediate tumor cell lysis
CD338 antigens ABCG2, BCRP, Bcrp1, MXR Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain and cancer cells
CD339 antigens Jagged-1, JAG1, JAGL1, hJ1 Ligand for multiple Notch receptors. Involved in the mediation of Notch signaling, cell fate determination in hematopoiesis and cardiovascular development
CD340 antigens ERBB2, MLN 19 Binds tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways
CD344 antigens Frizzled-4, Fz-4, FzD4 Receptor for Wnt proteins
CD350 antigens Frizzled-10, Fz-10, FZD10 Receptor for Wnt proteins
CD351 antigens FCAMR, Fcα/μR Fc receptor that binds IgM with high affinity and IgA with a 10-fold lower affinity
CD352 antigens NTB-A, SLAMF6, LY108 Triggers cytolytic activity only in NK cells expressing high surface densities of natural cytotoxicity receptors
CD353 antigens SLAMF8 Regulates macrophage function; may play a role in B cell lineage commitment
CD354 antigens TREM-1 Stimulates neutrophil and monocyte-mediated inflammatory responses.Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers
CD355 antigens CRTAM Interaction with CADM1 promotes NK cell cytotoxicity and IFN-gamma secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo
CD357 antigens TNFRSF18, GITR Receptor for TNFSF18
CD358 antigens TNFRSF21 May activate NFkB and promote apoptosis. May activate JNK and be lymphocytes. involved in T-cell differentiation. Required for both normal cell body death and axonal pruning
CD360 antigens IL-21R Receptor for interleukin-21.
CD361 antigens EVI2, BEVDB, D17S376 Cell adhesion, and immune response.
CD362 antigens Syndecan-2, HSPG, SDC2 Cell surface proteoglycan that bears heparan sulfate
CD365 antigens HAVCR1, HAVCR, KIM-1, TIM, TIM-1, TIMD1 as a stimulatory molecule for T-cell activation
CD366 antigens TIM-3, TIMD3 T-cell exhaustion, immune checkpoint
CD367 antigens DCIR, DDB27, CLECSF6, CLEC4A cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response
CD368 antigens MCL, CLECSF8, CLEC-6, MPCL, CLEC4D cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response
CD369 antigens DECTIN-1, CLECSF12, CLEC7A cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response
CD370 antigens HEEE9341, UNQ9341, DNGR1, CLEC9A cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response
CD371 antigens CLL-1, MICL, DCAL-2, CLEC12A cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response
Back to top

Cluster of differentiation

The cluster of differentiation (or cluster of designation), often abbreviated as CD, is a protocol used for the identification and investigation of cell surface molecules present on white blood cells (cells of the immune system). The cluster of differentiation nomenclature was proposed for the classification of the many monoclonal antibodies (mAbs) generated by different laboratories around the world against epitopes on the surface molecules of leukocytes. Since then, the use of cluster of differentiation has expanded to many other cell types, and for humans CD is numbered up to 350 most recently (as of 2009)

The human cluster of differentiation (CD) antigens constitute a promising assay content for antibody microarray applications, because of their common expression at the leukocyte cell surface and the fact that the majority perform critical functions in the human immune response. The diagnostic potential of a microarray, containing 82 cluster of differentiation monoclonal antibodies (DotScan microarrays) has been demonstrated for a variety of infectious and neoplastic disease states, including HIV, many acute and chronic leukemias, and colorectal cancer. It is likely that these cluster of differentiation monoclonal antibody microarrays will have more general utility that extends to other pathological categories, including autoimmune, metabolic, and degenerative diseases.

Cluster of differentiation antigens are not merely markers on the cell surface. Cluster of differentiation antigens can act in numerous ways and are important for immune reactions of organisms. They often act as receptors or ligands important to the cell, initiating a signal cascade and altering the behavior of the cell. Some cluster of differentiation antigens do not play a role in cell signaling, but have other functions, such as cell adhesion.

CD Antigens References

Zola H, et al. (2005) CD molecules 2005: human cell differentiation molecules. Blood. 106(9):3123-6.
Woolfson A, et al. (2006) The application of CD antigen proteomics to pharmacogenomics. Pharmacogenomics 7(5):759-71.
Ellmark P, et al. (2008) The applicability of a cluster of differentiation monoclonal antibody microarray to the diagnosis of human disease. Methods Mol Biol. 439:199-209.
Sakamoto K, et al. (2009) Expression of cluster of differentiation 9 glycoprotein in benign and malignant parotid gland tumours. J Laryngol Otol Suppl. (31):58-63.
Sakamoto K, et al. (2009) Expression of cluster of differentiation 9 glycoprotein in benign and malignant parotid gland tumours. J Laryngol Otol Suppl. (31):58-63.
Lal S, et al. (2009) Using antibody arrays to detect microparticles from acute coronary syndrome patients based on cluster of differentiation (CD) antigen expression. Mol Cell Proteomics. 8(4):799-804.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"