cIAP1 / BIRC2 Protein

Baculoviral IAP Repeat-Containing 2

cIAP1 / BIRC2 Products

cIAP1 / BIRC2 Protein, Recombinant

Molecule	Species	Description	Cat. No
cIAP1/BIRC2	Human	cIAP1/BIRC2 Protein, Recombinant, With AVI Tag	11090-H17E

  11090-H17E: The IC50 for this effect is typically 450-750 nM . Measured by its ability to inhibit DEVD-AFC cleavage activity in cell extracts activated by addition of cytochrome c and dATP.

cIAP1 / BIRC2 cDNA Clone

Molecule	Species	Description	Cat. No
cIAP1/BIRC2	Human	Homo sapiens cIAP1/BIRC2 cDNA Clone	HG11090-M
cIAP1/BIRC2	Mouse	Mouse cIAP1/BIRC2 cDNA Clone / ORF Clone	MG50761-G

cIAP1 / BIRC2 Related Areas

Enzyme>>Protease & Regulator>>Cysteine Protease & Regulator>>Inhibitor of Apoptosis (IAP)>>cIAP1/BIRC2

Cancer>>Apoptosis>>Inhibitor of Apoptosis (IAP)>>cIAP1/BIRC2

cIAP1 / BIRC2 Alternative Names

cIAP1, BIRC2, c-IAP1, HIAP2, Hiap-2, API1, MIHB, RNF48 [Homo sapiens]

cIAP1, Birc2, mcIAP1, cIAP2, HIAP1, HIAP2, AW146227, Api1, Api2, Birc3, IAP1, IAP2, MIAP1, MIAP2, MIHB, MIHC, RNF48 [Mus musculus]

 

cIAP1 / BIRC2 Background

The cellular inhibitor of apoptosis protein-1 (cIAP1) is a member of the Inhibitor of Apoptosis family proteinsare (IAP) whose members are characterized by a novel domain of about 70 amino acids termed baculoviral IAP repeats (BIRs). The BIR domains of cIAP1 and cIAP2 bind to caspases, the key effector proteases of apoptosis. The IAP protein family which can enhance cell survival are crucial regulators of programmed cell death. Both cIAP1 and cIAP2 are the E3 ubiquitin protein isopeptide ligases for Smac, taking part in promoting cancer survival through functioning as E3 ubiqitin ligases. Removal of cIAP1 by genetic deletion may result in NF-κB signaling activation that induces TNFα production and in killing sensitive tumor cells through enhanced TNF-R1 death-receptor signaling and caspase 8 activation. The substrate-dependent E3 activity of cIAPs is mediated by their RING domains and is dependent on the specific interactions between cIAPs and Smac. cIAP1 and cIAP2 are also reported to be regulators of NF-kB activation upon TNFαtreatment.

cIAP1 / BIRC2 Related Studies

1. Vince JE, et al. (2007) IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis. Cell. 131(4): 682-93.
2. Hu SM, et al. et al. (2003) Cellular Inhibitor of Apoptosis 1 and 2 Are Ubiquitin Ligases for the Apoptosis Inducer Smac/DIABLO. The Journal of Biological Chemistry. 278: 10055-60.
3. Imoto I, et al. (2011) Identification of cIAP1 As a Candidate Target Gene within an Amplicon at 11q22 in Esophageal Squamous Cell Carcinomas 1. Cancer Res. 61: 6629.