C2 cDNA Clone: Expression and Clone Vector / Plasmid
C2 cDNA / Gene Overview
C2 gene / cDNA is a protein-coding gene which located on 6p21.33. The C2 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog.113 organisms have orthologs with human gene C2.
Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]
C2 cDNA / Gene Sequence
LOCUS NM_000063 2862 bp mRNA linear PRI 30-JUN-2018
Homo sapiens complement C2 (C2), transcript variant 1, mRNA.
This sequence information is just for reference only.
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