CSK: CSK Protein | CSK Antibody

CSK Gene family

CSK Background

The tyrosine kinase c-Src has been implicated as a modulator of cell proliferation, spreading, and migration. These functions are also regulated by Met. The structure of a large fragment of the c-Src kinase comprises the regulatory and kinase domains and the carboxy-terminal tall. c-Src kinase interactions among domains and is stabilized by binding of the phosphorylated tail to the SH2 domain. This molecule is locked in a conformation that simultaneously disrupts the kinase active site and sequesters the binding surfaces of the SH2 and SH3 domains. The structure shows how appropriate cellular signals, or transforming mutations in v-Src, could break these interactions to produce an open, active kinase. The protein-tyrosine kinase activity of c-Src kinase is inhibited by phosphorylation of tyr527, within the c-Src c-terminal tail. Genetic and biochemical data have suggested that this negative regulation requires an intact Src homology 2 (SH2) domain. Since SH2 domains recognize phosphotyrosine, it is possible that these two non-catalytic domains associate, and thereby repress c-Src kinase activity. Experiments have suggested that c-Src kinase plays a role in the biological behaviour of colonic carcinoma cells induced by migratory factors such as EGF, perhaps acting in conjunction with FAK to regulate focal adhesion turnover and tumour cell motility. Furthermore, although c-Src kinase has been implicated in colonic tumour progression, in the adenoma to carcinoma in vitro model c-Src is not the driving force for this progression but co-operates with other molecules in carcinoma development. <h2 id="bp_bold">References

Reference for CSK

  • Brauninger A. et al.,1992, Gene. 110: 205-11.
  • Sondhi D. et al., 1999,Biochemistry. 38(34): 11147-55.
  • Ogawa A. et al., 2002, J Biol Chem. 277(17): 14351-4.
  • Cole PA. et al., 2003, Curr Opin Chem Biol. 7(5): 580-5.
  • Baumeister U. et al., 2005,EMBO J. 24(9): 1686-95.

CSK Protein

CSK protein function

Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. {ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:9281320}.

CSK protein expression

Tissue specificity

Expressed in lung and macrophages.

CSK protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    450.00
  • Mass (Da)
    50.00

CSK Antibody

There are 2 CSK antibodies which are validated in multiple tissues with various applications, including WB, IHC-P, IP, ELISA. There are 2 CSK antibody for WB, 1 CSK antibody for IHC-P, 1 CSK antibody for IP, 1 CSK antibody for ELISA. Among all these CSK antibodies, there are 2 anti-CSK rabbit polyclonal antibodies . All the CSK anbodies are produced in house and all are in stock. CSK antibody customerized service is available.

CSK Gene

CSK gene / cDNA is a protein-coding gene which located on 15q24.1. The CSK gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, C.elegans, and frog.214 organisms have orthologs with human gene CSK.