c-Kit / CD117 Protein & Antibody

Cluster of Differentiation 117

c-Kit / CD117 Products

c-Kit / CD117 Protein, Recombinant

Molecule	Species	Description	Cat. No
c-Kit/CD117	Human	c-kit/CD117 Protein, Recombinant	11996-H08H
c-Kit/CD117	Human	KIT / c-KIT / CD117 (aa 540-972) Protein, Recombinant, GST Tag	11996-H20B1
c-Kit/CD117	Mouse	c-kit/CD117/Fc Protein, Recombinant	50530-M02H
c-Kit/CD117	Mouse	c-kit/CD117 Protein, Recombinant	50530-M08H

  11996-H08H: Immobilized human KIT at 20 µg/ml (100 µl/well) can bind biotinylated mouse KITL with a linear ranger 1.28-6.4 ng/ml. Measured by its binding ability in a functional ELISA.

  50530-M02H: Immobilized mouse KITL at 2 µg/ml (100 µL/well) can bind mouse KIT / CD117 with a linear ranger of 1.28-32 ng/ml. Measured by its binding ability in a functional ELISA.

  50530-M08H: Immobilized mouse KIT at 2 µg/ml (100 µl/well) can bind biotinylated mouse KITL with a linear ranger of 1.28-6.4 ng/ml. Measured by its binding ability in a functional ELISA.

c-Kit / CD117 Antibody

Molecule	Application	Description	Cat. No
Human c-Kit/CD117	WB, ELISA	c-Kit / CD117 / KIT Antibody (Antigen Affinity Purified)	11996-RP02
Mouse c-Kit/CD117	WB, ELISA	c-Kit / CD117 / KIT Antibody	50530-RP01
Mouse c-Kit/CD117	WB, ELISA	c-Kit / CD117 / KIT Antibody (Antigen Affinity Purified)	50530-RP02

c-Kit / CD117 cDNA Clone

Molecule	Species	Description	Cat. No
c-Kit/CD117	Human	Home sapiens c-kit/CD117 cDNA Clone	HG11996-G
c-Kit/CD117	Mouse	Mus musculus c-kit/CD117 cDNA Clone	MG50530-M
c-Kit/CD117	Rat	KIT cDNA Clone / ORF Clone	RG80321-G

c-Kit / CD117 Related Areas

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hematopoietic Stem Cell Marker>>c-Kit/CD117

Immunology>>Cluster of Differentiation>>Hematopoietic Stem Cell CD Marker>>c-Kit/CD117

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>c-Kit/CD117

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>c-Kit/CD117

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>c-Kit/CD117

c-Kit / CD117 Alternative Names

c-Kit, CD117, PBT, SCFR [Homo sapiens]

c-KIT, CD117, SCFR, Bs, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, SCO1, SCO5, SOW3, Ssm, Tr-kit, W [Mus musculus]

c-Kit / CD117 Background

C-Kit is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains.and 1 protein kinase domain. It belongs to the protein kinase superfamily, tyr protein kinase family and CSF-1/PDGF receptor subfamily. C-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. C-Kit has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase. Antibodies to c-Kit are widely used in immunohistochemistry to help distinguish particular types of tumour in histological tissue sections. It is used primarily in the diagnosis of GISTs. In GISTs, c-Kit staining is typically cytoplasmic, with stronger accentuation along the cell membranes. C-Kit antibodies can also be used in the diagnosis of mast cell tumours and in distinguishing seminomas from embryonal carcinomas. Mutations in c-Kit gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Defects in KIT are a cause of acute myelogenous leukemia (AML). AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development. Note=Somatic mutations that lead to constitutive activation of KIT are detected in AML patients.

c-Kit / CD117 Related Studies

1. Andre C, et al. (1997) Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes. Genomics. 39(2):216-26.
2. Yarden Y, et al. (1987) Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J. 6(11):3341-51.
3. Leong KG, et al. (2008) Generation of a prostate from a single adult stem cell. Nature. 456(7223): 804-8.
4. Edling CE, et al. (2007) c-Kit--a hematopoietic cell essential receptor tyrosine kinase. Int J Biochem Cell Biol. 39(11):1995-8.
5. McIntyre A, et al. (2005) Amplification and overexpression of the KIT gene is associated with progression in the seminoma subtype of testicular germ cell tumors of adolescents and adults. Cancer Res. 65(18):8085-9.