c-Abl / ABL1 Protein

c-abl oncogene 1, receptor tyrosine kinase

c-Abl / ABL1 Products

c-Abl / ABL1 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
c-Abl/ABL1	Human	c-Abl/ABL1 Protein, Recombinant, With GST Tag	11199-H09B

c-Abl / ABL1 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
c-Abl/ABL1	Human	Homo sapiens c-Abl/ABL1 cDNA Clone	HG11199-M

c-Abl / ABL1 Related Areas

Enzyme>>Protein Kinase>>Intracellular Kinase>>c-Abl/ABL1

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>c-Abl/ABL1

c-Abl / ABL1 Alternative Names

c-ABL, ABL1, RP11-83J21.1, ABL, JTK7, bcr/abl, p150, v-abl [Homo sapiens]

c-Abl, Abl1, RP23-65P13.3, AI325092, Abl, E430008G22Rik, MGC117749 [Mus musculus]

c-Abl / ABL1 Background

c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity and tau phosphorylation. c-Abl has been implicated in many cellular processes including differentiation, division, adhesion, death, and stress response. c-Abl is a latent tyrosine kinase that becomes activated in response to numerous extra- and intra-cellular stimuli. The c-Abl protein is a ubiquitously expressed nonreceptor tyrosine kinase involved in the development and function of many mammalian organ systems, including the immune system and bone. It regulates the cellular response to tamoxifen (TAM) through functional interaction with the estrogen receptor, which suggests c-Abl as a therapeutic target and a prognostic tumor marker for breast cancer. c-Abl also plays a key role in signaling chemokine-induced T-cell migration. In addition, c-Abl contains NLSs (nuclear localization signals) and DNA-binding sequences important for nuclear functions. c-Abl has become an important therapeutic target in human chronic myeloid leukaemia.

c-Abl / ABL1 Related Studies

Zhao H, et al. (2010) Enhanced resistance to tamoxifen by the c-ABL proto-oncogene in breast cancer. Neoplasia. 12(3): 214-23.
Qiu Z, et al. (2010) c-Abl tyrosine kinase regulates cardiac growth and development. Proc Natl Acad Sci U S A. 107(3): 1136-41.
Huang Y, et al. (2008) The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse. Blood. 112(1): 111-9.
Sirvent A, et al. (2008) Cytoplasmic signalling by the c-Abl tyrosine kinase in normal and cancer cells. Biol Cell. 100(11): 617-31.
Shaul Y, et al. (2005) Role of c-Abl in the DNA damage stress response. Cell Res. 15(1): 33-5.