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beta-Catenin/CTNNB1

beta-Catenin/CTNNB1 Protein & Antibody

Entrez Gene Summary for beta-Catenin/CTNNB1


The protein encoded by CTNNB1 gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in CTNNB1 gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this CTNNB1 gene.

OMIM-Description for beta-Catenin/CTNNB1


Beta-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete (summary by Peifer, 1993).

.zh=beta-Catenin/CTNNB1


Catenin (cadherin-associated protein), beta 1, 88kDa (the HUGO-approved official symbol, CTNNB1; HGNC ID, HGNC:2514), also called beta-catenin (or β-catenin), is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. In Drosophila, the homologous protein is called armadillo. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin.

beta-Catenin/CTNNB1 Alternative Names

CTNNB,MRD19,armadillo, [homo-sapiens]
CTNNB,CTNNB1,OK/SW-cl.35,DKFZp686D02253,FLJ25606,FLJ37923, [human]
catenin beta-1,Catnb,Mesc,beta-Catenin,Bfc,CTNNB1, [mouse]
Bfc,Mesc,Catnb, [mus-musculus]
Catnb, [Rat]

beta-Catenin/CTNNB1 Related Products

beta-Catenin/CTNNB1 Proteins

Product nameProduct name
Human beta-Catenin / CTNNB1 Protein (His & GST Tag)Mouse beta-Catenin / CTNNB1 Protein (His & GST Tag)

beta-Catenin/CTNNB1 Antibodies

Product nameProduct name
beta-Catenin / CTNNB1 Antibody, Rabbit MAbbeta-Catenin / CTNNB1 Antibody, Rabbit PAb, Antigen Affinity Purifiedbeta-Catenin / CTNNB1 Antibody, Rabbit PAb

beta-Catenin/CTNNB1 cDNA Clones

Product nameProduct name
Human beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, N-His tagHuman beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, C-Myc tagMouse beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, N-HA tagHuman beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, N-Flag tagMouse beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, C-HA tagMouse beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tagHuman beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmidHuman beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, N-HA tagMouse beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, C-Myc tagHuman beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, C-HA tagMouse beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, C-His tagRat beta-Catenin/CTNNB1 Gene ORF cDNA clone in cloning vectorMouse beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, N-Flag tagHuman beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tagHuman beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, C-His tagMouse beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, C-Flag tagHuman beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tagHuman beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tagHuman beta-Catenin/CTNNB1 Gene ORF cDNA clone in cloning vectorHuman beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, C-Flag tagMouse beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmidHuman beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tagMouse beta-Catenin/CTNNB1 Gene ORF cDNA clone in cloning vectorMouse beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tagHuman beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, C-HA tagMouse beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, N-Myc tagHuman beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, N-Myc tagMouse beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tagMouse beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tagMouse beta-Catenin/CTNNB1 Gene ORF cDNA clone expression plasmid, N-His tag

beta-Catenin/CTNNB1 ELISA

Product nameProduct name
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