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beta-Catenin / CTNNB1 Protein & Antibody

Catenin (cadherin-associated protein), beta 1

beta-Catenin / CTNNB1 Products

beta-Catenin / CTNNB1 Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
beta-Catenin/CTNNB1 Human beta-Catenin/CTNNB1 Protein, Recombinant, with GST Tag 11279-H20B
beta-Catenin/CTNNB1 Mouse beta-Catenin/CTNNB1 Protein, Recombinant, with GST Tag 50592-M20B

beta-Catenin / CTNNB1 Antibody

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human beta-Catenin/CTNNB1 WB, ELISA beta-Catenin / CTNNB1 Antibody (Antigen Affinity Purified) 11279-RP02

beta-Catenin / CTNNB1 cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
beta-Catenin/CTNNB1 Human Human beta-Catenin/CTNNB1 cDNA Clone / ORF Clone HG11279-M
beta-Catenin/CTNNB1 Mouse Mouse beta-Catenin/CTNNB1 cDNA Clone / ORF Clone MG50592-M

beta-Catenin / CTNNB1 Related Areas

Signal Transduction>>Transcription Factor & Regulator>>beta-Catenin/CTNNB1

Stem Cell>>Embryonic Stem Cell (ESC)>>Embryonic Cell Lineage Marker>>beta-Catenin/CTNNB1

beta-Catenin / CTNNB1 Alternative Names

CTNNB1, OK/SW-cl.35, CTNNB, DKFZp686D02253, FLJ25606, FLJ37923 [Homo sapiens]

beta-Catenin, CTNNB1, Bfc, Catnb, Mesc, catenin beta-1 [Mus musculus]

beta-Catenin / CTNNB1 Background

beta-Catenin, also known as CTNNB1, is a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain, which is specialized for protein-protein binding. It is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. CTNNB1 also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, beta-Catenin binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Defects in beta-Catenin can cause colorectal cancer, pilomatrixoma (PTR), medulloblastoma, and ovarian cancer. CTNNB1 is a key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, it forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, beta-Catenin is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. CTNNB1 is involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.

beta-Catenin / CTNNB1 Related Studies

  1. Yang, et al. (2002) Linking β-catenin to androgen-signaling pathway. J Biol Chem. 277(13):11336-44.
  2. Hino S, et al. (2005) Phosphorylation of β-Catenin by Cyclic AMP-Dependent Protein Kinase Stabilizes β-Catenin through Inhibition of Its Ubiquitination. Mol Cell Biol. 25(20):9063-72.
  3. Liu X, et al. (2005) Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins. Curr Biol. 15(22):1989-97.
  4. Kraus C, et al. (1994) Localization of the human β-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development. Genomics. 23(1):272-4.