beta-Catenin (Protein|Antibody|cDNA Clone|ELISA Kit)

All beta-Catenin reagents are produced in house and quality controlled, including 3 beta-Catenin Antibody, 32 beta-Catenin Gene, 1 beta-Catenin IPKit, 2 beta-Catenin Lysate, 2 beta-Catenin Protein, 2 beta-Catenin qPCR. All beta-Catenin reagents are ready to use.

Recombinant beta-Catenin proteins are expressed by Baculovirus-Insect Cells with fusion tags as N-GST & His.

beta-Cateninantibodies are validated with different applications, which are ELISA, IHC-P, ICC/IF, IF, IP.

beta-CatenincDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each beta-Catenin of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

beta-Catenin Protein (2)

Species

beta-Catenin Protein, Human, Recombinant (His & GST Tag)

11279-H20B

Expression host: Baculovirus-Insect Cells

Human beta-Catenin/CTNNB1 Protein 9519

beta-Catenin Protein, Mouse, Recombinant (His & GST Tag)

50592-M20B

Expression host: Baculovirus-Insect Cells

Mouse beta-Catenin/CTNNB1 Protein 11757
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beta-Catenin Antibody (3)

Application Clonality
Host

Anti-beta-Catenin Antibody

11279-RP01

Application: ELISA

Clonality: PAb

Anti-beta-Catenin Antibody

11279-R021

Application: ELISA,IHC-P,ICC/IF,IF,IP

Clonality: MAb

Human beta-Catenin/CTNNB1 Immunohistochemistry(IHC) 2949

Anti-beta-Catenin Antibody

11279-RP02

Application: ELISA,IHC-P

Clonality: PAb

Human beta-Catenin/CTNNB1 Immunohistochemistry(IHC) 4331
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beta-Catenin cDNA Clone (32)

Rat
Human
Mouse

beta-Catenin qPCR Primer (2)

beta-Catenin IP Kit (1)

beta-Catenin Lysate (2)

beta-Catenin, also known as CTNNB1, is a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain, which is specialized for protein-protein binding. It is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. CTNNB1 also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, beta-Catenin binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Defects in beta-Catenin can cause colorectal cancer, pilomatrixoma (PTR), medulloblastoma, and ovarian cancer. CTNNB1 is a key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, it forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, beta-Catenin is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. CTNNB1 is involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.

Protein
Antibody
Gene
qPCR
IPKit
Lysate
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