Monoclonal Antibody (Mab) Engineering: Chimeric Antibody

Monoclonal Antibody Chimeric Engineering

Monoclonal Antibody chimerization is an important and powerful tool to reduce antibody’s immunogenicity when injected into a different species. Chimerization or humanization is also a must-do step to convert a mouse monoclonal antibody into a therapeutic antibody candidate for human use. Even for in vitro applications such as Immunohistochemistry studies or ELISA assay development, switching the antibody constant regions to match the species of the host or secondary antibody could significantly reduce the background staining.

Switching the constant gene fragment of a monoclonal antibody may or may not affect the monoclonal antibody’s binding affinity to the target antigen. Hence experience and design of multiple constructs may be necessary to ensure good binding affinity after chimerization. Sino Biological has extensive experience and expertise in monoclonal antibody chimerization. We offer this service free of charge in our package of recombinant monoclonal antibody production service using any of our multiple platform technologies.

Monoclonal Antibody Chimeric Engineering Related Services and Products

• Mouse Monoclonal Antibody Development
• Rabbit Monoclonal Antibody Development
• Antibody Humanization Services