|All Antibody Services||All Protein Services||All Gene Services||All Biological Services|
|Service:||Human or humanized antibody Fc engineering
1. Antibody ADCC and CDC function modification (enhanced or weakened)
2. Antibody Pharmacokinetics optimization
|Technology:||Antibody Fc region amino acid mutation & modification
Recombinant antibody expression
|Production Host:||HEK293 or CHO cell transient transfection for antibody production
2-3 weeks for specific Fc antibody expression vector constuction
2-3 weeks for 0.5~2mg antibody production
1 week for FcR receptor, C1 complement and FcRn binding activity
Cell based ADCC, CDC or monkey in vivo pharmokinetics service, please inquire.
|Deliverable:||4~10 Fc-engineered antibody sequences
1 – 2 mg purified antibody for each molecule
Larger quantity of antibody production can be requested
(please refer to our antibody production service).
|Applications:||therapeutic antibody discovery & development|
|Quotation:||on-line request form or e-mail request to CROfirstname.lastname@example.org|
Antibody's complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC) function is crucial for its anti-cancer efficacy. On the other hand, for some non-cancer treatments, antibody's CDC and ADCC function may not be desirable. So apparently, sometimes one would desire to increase an antibody's CDC and ADCC activities and some other times, one may prefer to eliminate or reduce an antibody's CDC and ADCC function. To achieve such a goal, one could modify the antibody's Fc region where the antibody interacts with and binds to Fc receptor proteins on human immune cells.
Sino Biological has developed a comprehensive set of...... <Learn More>