alpha-2-macroglobulin Protein (A2M Protein)

alpha-2-macroglobulin Products

alpha-2-macroglobulin Protein, Recombinant

Molecule	Species	Description	Cat. No
alpha-2-macroglobulin/A2M	Human	alpha-2-macroglobulin Protein, Recombinant	10952-H08B

alpha-2-macroglobulin cDNA Clone

Molecule	Species	Description	Cat. No
alpha-2-macroglobulin/A2M	Human	Human alpha-2-Macroglobulin/A2M cDNA Clone / ORF Clone	HG10952-M

alpha-2-macroglobulin Related Areas

Enzyme>>Protease & Regulator>>Aspartate Protease & Regulator>>alpha-2-macroglobulin/A2M

Enzyme>>Protease & Regulator>>Cysteine Protease & Regulator>>alpha-2-macroglobulin/A2M

Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>alpha-2-macroglobulin/A2M

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>alpha-2-macroglobulin/A2M

alpha-2-macroglobulin Alternative Names

alpha-2-macroglobulin, A2M, FWP007, CPAMD5, DKFZp779B086, S863-7 [Homo sapiens]

alpha-2-macroglobulin, A2m, A2mp [Mus musculus]

alpha-2-macroglobulin Background

alpha-2-macroglobulin, also known as α2-macroglobulin (α2M and A2M), is an abundant protein of the plasma of vertebrates and members of several invertebrate phyla and functions as a broad-spectrum protease-binding protein. alpha-2-macroglobulin is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis. alpha-2-macroglobulin is a large plasma glycoprotein that has long been known as an irreversible inhibitor of a variety of proteinases. More recently, it has been reported that numerous growth factors, cytokines and hormones bind to alpha 2M through diverse mechanisms. A2M is also produced in the brain where it binds multiple extracellular ligands and is internalized by neurons and astrocytes. In the brain of Alzheimer's disease (AD) patients, A2M has been localized to diffuse amyloid plaques. A2M also binds soluble beta-amyloid, of which it mediates degradation. Protease-conjugated alpha2-macroglobulin is selectively bound by cells contacting the body fluids and alpha2-macroglobulin and its protease cargo are then internalized and degraded in secondary lysosomes of those cells. In addition to this function as an agent for protease clearance, alpha2-macroglobulin binds a variety of other ligands, including several peptide growth factors and modulates the activity of a lectin-dependent cytolytic pathway in arthropods.

alpha-2-macroglobulin Related Studies

1. Kovacs DM. (2000) alpha2-macroglobulin in late-onset Alzheimer's disease. Exp Gerontol. 35(4): 473-9.
2. Armstrong PB, et al. (1999) Alpha2-macroglobulin: an evolutionarily conserved arm of the innate immune system. Dev Comp Immunol. 23(4-5): 375-90.
3. Feige JJ, et al. (1996) Alpha 2-macroglobulin: a binding protein for transforming growth factor-beta and various cytokines. Horm Res. 45(3-5): 227-32.