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Adoptive Immunotherapy

Adoptive immunotherapy, or cell therapies, is undergoing a period of growth and enthusiasm following encouraging data regarding its clinical efficacy. Virus-directed adoptive immunotherapies are under investigation for the treatment of chronic viral infections such as HIV and for viruses that cause morbidity and mortality in immunosuppressed settings such as bone marrow transplantation. In addition, adoptive immunotherapies are poised to take a prominent role in both hematologic malignancies and solid tumors.

Adoptive Immunotherapy for Viruses

The first clinical use of chimeric antigen receptor (CAR)-modified T cells was in HIV infection. In this setting, the CAR was composed of the receptor for the HIV envelope protein, namely the extracellular and transmembrane portions of the CD4 protein, fused to the T cell receptor (TCR)-ζ signaling molecule (CD4z CAR). The proposed mechanism of action was for transduced T cells to lyse HIV envelope–expressing T cells……

Adoptive Immunotherapy for Cancer

Immunotherapy for cancer has a long and somewhat checkered history; the first observations that immune system engagement has antitumor effects are often attributed to William Coley, who observed regression of sarcoma following severe bacterial infections in the 1890s. However, the seminal finding that allogeneic immune reconstitution after bone marrow transplant had antileukemic effects definitively identified the anticancer effects of immune cells……

Adoptive Immunotherapy: Reference

Maus MV et al. Adoptive Immunotherapy for Cancer or Viruses. Annual review of immunology. 2014;32:189-225.

What is Immunotherapy
Cancer Immunotherapy
- What is Immunotherapy for Cancer
- Monoclonal Antibody for Cancer Immunotherapy
- Immune Checkpoint
- Vaccines for Cancer Immunotherapy
- Immune Modulation for Cancer Immunotherapy
- Oncolytic Viruses for Cancer Immunotherapy
- Adoptive Immunotherapy for Cancer
- Immunotherapy for Lung Cancer
- Immunotherapy for Melanoma
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- Immunotherapy for Colon Cancer
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Allergy Immunotherapy
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- Immunotherapy for Cat Allergy
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- Allergy Shots (Immunotherapy)
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Autoimmune Diseases Immunotherapy
- Immunotherapy for Autoimmune Diseases: Rheumatoid Arthritis
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- Immunotherapy for Autoimmune Diseases: Systemic Lupus Erythematosus
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Immunotherapy Related Molecules
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- Side Effects of Immunotherapy for Cancer
- Side Effects of Allergy Immunotherapy
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Immunotherapy Drugs
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- Immunotherapy Drugs for Allergy
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Adoptive Immunotherapy
- Adoptive Immunotherapy for Virus
- Adoptive Immunotherapy for Cancer
Journal of Immunotherapy
Immunotherapy Conference
Targeted Therapy