ABP1 / AOC1 (Protein | Antibody | cDNA Clone | ELISA Kit)

All ABP1 / AOC1 reagents are produced in house and quality controlled, including 4 ABP1 / AOC1 Antibody, 39 ABP1 / AOC1 Gene, 1 ABP1 / AOC1 Lysate, 1 ABP1 / AOC1 Protein, 1 ABP1 / AOC1 qPCR. All ABP1 / AOC1 reagents are ready to use.

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ABP1 / AOC1 Background

Amine oxidase copper-containing 1 (AOC1; formerly known as amiloride-binding protein 1) is a secreted glycoprotein that catalyzes the degradation of putrescine and histamine. Polyamines and their diamine precursor putrescine are ubiquitous to all organisms and fulfill pivotal functions in cell growth and proliferation. That the Wilms tumor protein, WT1, which is necessary for normal kidney development, activates transcription of the AOC1 gene. Expression of a firefly luciferase reporter under control of the proximal AOC1 promoter was significantly enhanced by co-transfection of a WT1 expression construct. Binding of WT1 protein to a cis-regulatory element in the AOC1 promoter was confirmed by electrophoretic mobility shift assay and chromatin immunoprecipitation. WT1-dependent control of polyamine breakdown, which is mediated by changes in AOC1 expression, has a role in kidney organogenesis.