YWHAE

YWHAE, also known as 14-3-3 epsilon, mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 epsilon / YWHAE is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm, and seven isoforms have been identified in mammals. This family of proteins was initially identified as adaptor proteins which bind to phosphoserine-containing motifs. Binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. 14-3-3 epsilon / YWHAE is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. YWHAE interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. 14-3-3 epsilon / YWHAE is implicated in the regulation of a large spectrum of both general and specialized signaling pathways. 14-3-3 epsilon / YWHAE Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. This Binding generally results in the modulation of the activity of the binding partner.

YWHAE Related Areas

Cancer>>Apoptosis>>Death Receptor & Ligand>>14-3-3 epsilon/YWHAE

Signal Transduction>>Adaptor Protein>>14-3-3 epsilon/YWHAE

YWHAE Alternative Names

14-3-3 epsilon, YWHAE, 14-3-3E, FLJ45465, FLJ53559, KCIP-1, MDCR, MDS [Homo sapiens]
14-3-3 epsilon, Ywhae, RP23-78H4.1, AU019196 [Mus musculus]

Summaries for YWHAE

Entrez Gene summary for YWHAE:

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene.

OMIM - description for YWHAE:

Features of the Miller-Dieker syndrome include classic lissencephaly (pachygyria, incomplete or absent gyration of the cerebrum), microcephaly, wrinkled skin over the glabella and frontal suture, prominent occiput, narrow forehead, downward slanting palpebral fissures, small nose and chin, cardiac malformations, hypoplastic male extrenal genitalia, growth retardation, and mental deficiency with seizures and EEG abnormalities. Life expectancy is grossly reduced, with death most often occurring during early childhood

Wikipedia summary for YWHAE:

14-3-3 protein epsilon is a protein that in humans is encoded by the YWHAE gene.[1] This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer.

Human YWHAE Protein General Information

 

• Protein names: 14-3-3 protein epsilon, Short name=14-3-3E
• Sequence length: 255 AA.
• Sequence similarities: Belongs to the 14-3-3 family.
• Subunit structure: Homodimer. Heterodimerizes with YWHAZ. Interacts with NDEL1, RGNEF and TIAM2 By similarity. Interacts with HCV core protein. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Weakly interacts with CDKN1B. Interacts with GAB2. Interacts with phosphorylated GRB10. Interacts with PKA-phosphorylated AANAT. Interacts with the phosphorylated (by AKT1) form of SRPK2.
• Subcellular location: Cytoplasm By similarity. Melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

General information above from UniProt

Function for YWHAE Protein

UniProtKB:

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Genatlas:

• YWHAE is inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase
• YWHAE multifunctional regulator required for cytoplasmic dynein function, neuronal migration and brain development
• implicated in the regulation of a large spectrum of both general and specialized signaling pathway
• YWHAE playing a crucial role in neronal development by sustaining the effects of CDK5 phosphorylation
• involved in the proper localization of NDEL1 and PAFAH1B1 in axons
• YWHAE and DISC1, two schizophrenia susceptibility factors have been implicated in the regulation of spine density

Homology for human YWHAE

• ortholog to rattus Ywhae (98.8pc)
• ortholog to murine Ywhae (99.6pc)