YKL-39 / CHI3L2 Protein & Antibody

Chondrocyte protein 39 / Chitinase 3-like 2

YKL-39 / CHI3L2 Products

YKL-39 / CHI3L2 Protein, Recombinant

Molecule	Species	Description	Cat. No
YKL-39/CHI3L2	Human	YKL-39/CHI3L2 Protein, Recombinant	12162-H08H

YKL-39 / CHI3L2 Antibody

Molecule	Application	Description	Cat. No
Human YKL-39/CHI3L2	WB, ELISA	YKL-39 / CHI3L2 Antibody (Antigen Affinity Purified)	12162-RP02

YKL-39 / CHI3L2 cDNA Clone

Molecule	Species	Description	Cat. No
YKL-39/CHI3L2	Human	CHI3L2 cDNA Clone / ORF Clone	HG12162-G

YKL-39 / CHI3L2 Related Areas

Enzyme>>Carbohydrate Metabolism Enzymes>>YKL-39/CHI3L2

YKL-39 / CHI3L2 Alternative Names

YKL-39, CHI3L2, YKL39 [Homo sapiens]

YKL-39 / CHI3L2 Background

Chondrocyte protein 39 (YKL-39), also known as Chitinase 3-like 2 (CHI3L2), is a secretory protein of articular chondrocytes belonging to the glycosyl hydrolase 18 family. It highest expression is in chondrocytes, followed by synoviocytes, lung and heart. YKL-39/CHI3L2 is not detected in spleen, pancreas, and liver. YKL-39/CHI3L2 may also be expressed in developing brain and placenta. YKL-39/CHI3L2, a cartilage-related protein, is found to induce arthritis accompanied by pathologic changes in bone and cartilage. A better understanding of the immune response against cartilage-related components including YKL-39 may help to elucidate the pathological processes of arthritic disorders. Up regulation of YKL-39/CHI3L2 in osteoarthritic cartilage suggests that YKL-39/CHI3L2 may be a more accurate marker of chondrocyte activation than YKL-40, although it has yet to be established as a suitable marker in synovial fluid and serum. The decreased expression of YKL-40 by osteoarthritic chondrocytes is surprising as increased levels have been reported in rheumatoid and osteoarthritic synovial fluid, where it may derive from activated synovial cells or osteophytic tissue or by increased matrix destruction in the osteoarthritic joint. YKL-39 and YKL-40 are potentially interesting marker molecules for arthritic joint disease because they are abundantly expressed by both normal and osteoarthritic chondrocytes.

YKL-39 / CHI3L2 Related Studies

1. Sakata M, et al. (2002) YKL-39, a human cartilage-related protein, induces arthritis in mice. Clin Exp Rheumatol. 20(3): 343-50.
2. Areshkov PA, et al. (2010) Chitinase 3-like protein 2 (CHI3L2, YKL-39) activates phosphorylation of extracellular signal-regulated kinases ERK1/ERK2 in human embryonic kidney (HEK293) and human glioblastoma (U87 MG) cells. Tsitol Genet. 44(1): 3-9.
3. Steck E, et al. (2002) Enhanced expression of the human chitinase 3-like 2 gene (YKL-39) but not chitinase 3-like 1 gene (YKL-40) in osteoarthritic cartilage. Biochem Biophys Res Commun. 299(1): 109-15.