XIAP Protein (BIRC4 Protein)

X-linked Inhibitor of Apoptosis (Baculoviral IAP Repeat-Containing 4)

XIAP Products

XIAP Protein, Recombinant

Molecule	Species	Description	Cat. No
XIAP/BIRC4	Human	XIAP/BIRC4 Protein, Recombinant, With AVI Tag	10606-H17E

XIAP cDNA Clone

Molecule	Species	Description	Cat. No
XIAP/BIRC4	Human	Homo sapiens XIAP/BIRC4 cDNA Clone(NM_001167.2)	HG10606-M
XIAP/BIRC4	Mouse	Mouse XIAP/BIRC4 cDNA Clone / ORF Clone	MG50802-G

XIAP Related Areas

Enzyme>>Protease & Regulator>>Cysteine Protease & Regulator>>Inhibitor of Apoptosis (IAP)>>XIAP/BIRC4

Cancer>>Apoptosis>>Inhibitor of Apoptosis (IAP)>>XIAP/BIRC4

XIAP Alternative Names

XIAP, BIRC4, XLP2, RP1-315G1.5, API3, ILP1, MIHA [Homo sapiens]

Xiap, Birc4, RP23-207E14.3, 1110015C02Rik, Aipa, Api3, IAP3, ILP-1, MIHA, mXIAP [Mus musculus]

XIAP Background

E3 ubiquitin-protein ligase XIAP / BIRC4, also known as inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, and IAP-like protein, is a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. XIAP / BIRC4 functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. XIAP / BIRC4 also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this encoding gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Thought to be the most potent apoptosis suppressor, XIAP / BIRC4, directly binds and inhibits caspases -3, -7 and -9. Survivin, which also binds to several caspases, is up-regulated in a many tumour cell types. Defects in XIAP / BIRC4 are the cause of lymphoproliferative syndrome X-linked type 2 (XLP2). XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.

XIAP Related Studies

1. Holcik M, et al. (2000) Functional Characterization of the X-Linked Inhibitor of Apoptosis (XIAP) Internal Ribosome Entry Site Element: Role of La Autoantigen in XIAP Translation. Mol Cell Biol. 20 (13): 4648–57.
2. Winsauer G, et al. (2008) XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2. Cell Signal. 20 (11): 2107–12.
3. Suzuki Y, et al. (2001) X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes. J Biol Chem. 276 (29): 27058–63.