Anti-EDA2R Antibody

Cat: 11845-RP02
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Anti-EDA2R Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-EDA2R Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human EDA2R
Immunogen
Recombinant Human XEDAR / EDA2R protein (Catalog#11845-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human XEDAR / EDA2R (rh XEDAR / EDA2R; Catalog#11845-H08H; NP_068555.1; Met 1-Thr 138). XEDAR / EDA2R specific IgG was purified by Human XEDAR / EDA2R affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-EDA2R Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-EDA2R Antibody Alternative Names
Anti-EDA-A2R Antibody;Anti-EDAA2R Antibody;Anti-TNFRSF27 Antibody;Anti-XEDAR Antibody
EDA2R Background Information

Tumor necrosis factor receptor superfamily member 27, also known as X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, EDA2R, XEDAR and TNFRSF27, is a single-pass type I II membrane protein. TNFRSF27 / EDA2R contains three TNFR-Cys repeats. It is a new member of the tumor necrosis factor receptor family that has been shown to be highly expressed in ectodermal derivatives during embryonic development and binds to ectodysplasin-A2 (EDA-A2). TNFRSF27 / EDA2R is a receptor for EDA isoform A2, but not for EDA isoform A1. TNFRSF27 / EDA2R mediates the activation of the NF-kappa-B and JNK pathways. The activation seems to be mediated by binding to TRAF3 and TRAF6. Ectodysplasin, a member of the tumor necrosis factor family, is encoded by the anhidrotic ectodermal dysplasia EDA gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that differ only by an insertion of two amino acids. This insertion functions to determine receptor binding specificity, such that EDA-A1 binds only the receptor EDAR, whereas EDA-A2 binds only the related, but distinct, X-linked ectodysplasin-A2 receptor (XEDAR).

Full Name
ectodysplasin A2 receptor
References
  • Yan M., et al., 2000,Science. 290: 523-527.
  • Sinha S.K., et al., 2002, J. Biol. Chem. 277: 44953-44961.
  • Prodi, D.A. et al., 2008, J Invest Dermatol  128 (9):2268-70.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-EDA2R Antibody Rabbit Polyclonal ELISA 11845-T16
    Anti-EDA2R Antibody Rabbit Monoclonal ELISA 11845-R072
    Anti-EDA2R Antibody Mouse Monoclonal ELISA 11845-MM05
    Anti-EDA2R Antibody Rabbit Polyclonal ELISA 11845-RP01
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