All XCL2 reagents are produced in house and quality controlled, including 2 XCL2 Antibody, 1 XCL2 Gene, 1 XCL2 Lysate, 1 XCL2 Protein. All XCL2 reagents are ready to use.
Recombinant XCL2 proteins are expressed by Baculovirus-Insect Cells with fusion tags as C-His.
XCL2 antibodies are validated with different applications, which are ELISA.
XCL2 cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each XCL2 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
XCL2 is a small cytokine belonging to the XC chemokine family. Chemokines are a group of cytokines. Members of this group of so-called C-Chemokines belong to the SCY family of cytokines and are designated XCL (L for ligand) followed by a number. XCL2 is the new designation of SCM-1-beta. XCL2 is highly related to another chemokine called XCL1. XCL2 gene is located on chromosome 1 in humans. XCL2 is predominantly expressed in activated T cells, but can also be found at low levels in unstimulated cells. XCL2 induces chemotaxis of cells expressing the chemokine receptor XCR1. XCL2 gene has been proposed to participate in pathways (Chemokine signaling pathway, Cytokine-cytokine receptor interaction) and processes (blood circulation, signal transduction, chemotaxis, immune response). XCL2 are expected to have molecular function (chemokine activity) and to localize in various compartments (extracellular space, extracellular region). A putative protein interactor has been described (XCR1). The spliced mRNA putatively encodes a good protein, containing small cytokines (intecrine / chemokine), interleukin-8 like domain; the complete protein appears to be secreted.
Kennedy J, et al. (1995) Molecular cloning and functional characterization of human lymphotactin. J Immunol. 155(1):203-9.
Yoshida T, et al. (1998) Identification of single C motif-1 / lymphotactin receptor XCR. J Biol Chem. 273(26):16551-54.
Yoshida T, et al. (1996) Structure and expression of two highly related genes encoding SCM-1 / human lymphotactin. FEBS Lett. 395(1):82-8.