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Wnt Signaling Pathway

Sino Biological provides a comprehensive set of tools for studying Wnt Signaling Pathway, including active proteins, antibodies (mouse Mab, rabbit Mab and rabbit Pab) and cDNA clones.

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    Wnt Signaling Pathway Background

    Wnt signaling pathway involves a large number of proteins that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. The canonical Wnt signaling pathway has been elucidated in vertebrate and invertebrate model systems. The canonical Wnt signaling pathway is induced when Wnt proteins bind to cell-surface receptors of the Frizzled family, causing the receptors to activate Dishevelled family proteins and ultimately resulting in a change in the amount of beta-catenin that reaches the nucleus. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Other Wnt signaling pathways (non- canonical Wnt signaling pathways) include the planar cell polarity (PCP) pathway, the Wnt/Ca2+ pathway, and other. Wnt signaling pathway has been discovered to be involved in cancer. Chronic activation of the Wnt signaling pathway has been implicated in the development of a variety of human malignancies, including hepatocellular carcinomas (HCCs), colorectal carcinomas, melanomas and uterine and ovarian carcinomas. In addition, the Wnt signaling pathway, as well as the Hedgehog and Notch pathways, is thought to be involved in the occurrence of cancer stem cell. Some diverse roles of Wnt in axon guidance have also been discovered. An example is in the growing spinal cord commissural neurons: after their extending axons cross the midplate of the spinal cord, they are guided by a Wnt gradient, which is active through the frizzled receptors in this case.

    Wnt Signaling Pathway References

      1. Lyuksyutova AI, et al. (2003) Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling. Science. 302(5652):1984-8.
      2. Logan CY, et al. (2004) The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol. 20:781-810.
      3. Beachy PA, et al. (2004) Tissue repair and stem cell renewal in carcinogenesis. Nature. 432(7015):324-31.
      4. Katoh M, et al. (2007) WNT signaling pathway and stem cell signaling network. Clin Cancer Res. 13(14):4042-5.
      5. Qi J, et al. (2008) Targeting the most upstream site of Wnt signaling pathway provides a strategic advantage for therapy in colorectal cancer. Curr Drug Targets. 9(7):548-57.
      6. Staal FJ, et al. (2008) The canonical Wnt signaling pathway plays an important role in lymphopoiesis and hematopoiesis. Eur J Immunol. 38(7):1788-94.