+86-400-890-9989
Product Catalog
> Wnt Inhibitor Wnt Inhibitor
Sino Biological provides quality reagents of recombinant proteins of Wnt inhibitors, anti-Wnt inhibitor antibodies (for application of WB, ELISA, IHC, etc.), ELISA kits, and cDNA clones for research use.
Wnt Inhibitor Products
Please click the molecular formulas to find products that you are interested.
* Being developed. Tell us your requirement so that the products of interest be placed on the priority list.
Dkk Family
|
Secreted Frizzled Related Proteins (sFRP)
|
|
|
Other Wnt Inhibitors
|
|
Wnt Signaling Pathway Related Products Index
|
|
|
|
|
|
Canonical Wnt Pathway
Wnt Inhibitor Background
The extracellular inhibitors of the Wnt signalling pathway can be divided into two broad classes. Both classes of molecule prevent ligand-receptor interactions, but by different mechanisms: members of the first class, which include these creted Frizzled-related protein (sFRP) family, Wnt inhibitory factor-1 (WIF) and Cerberus, primarily bind to Wnt proteins; the second class comprises certain members of the Dickkopf (Dkk) family, which bind to one subunit of the Wnt receptor complex. In addition, there are other protein interactions that contribute to Wnt antagonist function. Moreover, certain sFRPs and Dkks do not antagonise Wnt function, which suggests that these families have as-yet-undiscovered functions.
Wnt Inhibitor Related Studies
- Kawano Y, et al. (2011) Secreted antagonists of the Wnt signaling pathway. J Cell Science. 124(15): 2627-34.
- Kim AS, et al. (2001) Wnt receptors and Wnt inhibitors are expressed in gradients in the developing telencephalon. Mechanisms of Development. 103(1-2): 167-72.
