Wilms Tumor 1 Associated Protein (WTAP)

Wilms' tumor 1-associating protein (WTAP) was previously identified as a protein associated with Wilms' tumor-1 (WT-1) protein that is essential for the development of the genitourinary system. WT1 was originally identified as a tumor suppressor for Wilms' tumor, but it is also overexpressed in a variety of cancer cells. The WTAP-WT1 axis in vascular cells suggest that WTAP is a vital and multifaceted regulator of vascular remodeling. WTAP has been suggested to function in alternative splicing, stabilization of mRNA, and cell growth. Knocking down endogenous WTAP increased Smooth muscle cells (SMCs) proliferation, because of increased DNA synthesis and G(1)/S phase transition, together with reduced apoptosis. These effects could be the result of WTAP suppressing the transcriptional activity of WT1 in SMCs. WTAP may thus also play a role in messenger RNA processing in mammalian cells, either dependent on or independent of its interaction with WT1.

Wilms Tumor 1 Associated Protein (WTAP) Related Areas

Signal Transduction>>Transcription Factor & Regulator>>WTAP

Wilms Tumor 1 Associated Protein (WTAP) Alternative Names

WTAP, RP1-56L9.4, DKFZp686F20131, KIAA0105, MGC3925 [Homo sapiens]

Wtap 2810408K05Rik, 9430038B09Rik [Mus musculus]

Summaries for Wilms Tumor 1 Associated Protein (WTAP)

Entrez Gene summary for Wilms Tumor 1 Associated Protein (WTAP):

The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. WTAP gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in three transcript variants, two of which encode the same isoform. [provided by RefSeq, Jul 2008]

Wikipedia summary for Wilms Tumor 1 Associated Protein (WTAP):

Pre-mRNA-splicing regulator WTAP is a protein that in humans is encoded by the WTAP gene.
The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in three transcript variants, two of which encode the same isoform.

Human Wilms Tumor 1 Associated Protein (WTAP) Protein General Information

 

• Protein names: Wilms Tumor 1 Associated Protein
  Short name=WTAP
• Sequence length: 396 AA.
• Induction: In smooth muscle cells, up-regulated after serum withdrawal, when cells become mature and non proliferative.
• Sequence similarities: Belongs to the fl(2)d family.
• Post-translational modification: Phosphorylated upon DNA damage, probably by ATM or ATR.
• Subunit structure: Interacts with WT1.
• Subcellular location: Nucleus › nucleolus
• Tissue specificity: Ubiquitously expressed.

General information above from UniProt

Function for Wilms Tumor 1 Associated Protein (WTAP) Protein

UniProtKB:

Wilms Tumor 1 associated protein regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. WTAP impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes. WTAP may be involved in mRNA splicing regulation.

Genatlas:

• Wilms Tumor 1 associated protein is involved in the morphogenesis of the genitourinaty tract
• Wilms Tumor 1 associated protein is essential factor for the stabilization of cyclin A2 mRNA, thereby regulating G2/M cell-cycle transition

Homology for human Wilms Tumor 1 Associated Protein (WTAP)

• homolog to murine Wtap
• homolog to drosophila female-lethal-2-D