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ELISA Antibody to IGFBP3 Products
Sino Biological is the new leader in life science research tool developer worldwide. All our proteins are manufactured in bulk quantities using sequence verified vectors and state-of-the-art mammalian, insect, or E. coli expression processes. All reagents are available in both small retails and bulk packages - both offering 30-80% cost saving compared to currently leading brands. We installed the same quality requirement and assurance for preclinical products to reagent products, hence the quality of Sino Biological products is typically higher than that of other reagent providers.
Sino Biological Inc offers quality ELISA Antibody to IGFBP3 Products for research.
Browse ELISA Antibody to IGFBP3 Products by following categories
IGFBP3 Protein , Antibody, ELISA Kit, cDNA Clone
ELISA Antibody to IGFBP3
– ELISA Antibody to Human IGFBP3
– ELISA Antibody to Mouse IGFBP3
– ELISA Antibody to Rat IGFBP3
– ELISA Antibody to Rhesus IGFBP3
– ELISA Antibody to Cynomolgus IGFBP3
– ELISA Antibody to Canine (Dog) IGFBP3
– ELISA Antibody to Ferret IGFBP3
– ELISA Antibody to Bovine IGFBP3
Antibody to IGFBP3
ELISA Antibody to IGFBP3 Products
All IGFBP3 Products list
ELISA Antibody to IGFBP3 Related Products
Western Blot Antibody to IGFBP3
– Western Blot Antibody to Human IGFBP3
– Western Blot Antibody to Mouse IGFBP3
– Western Blot Antibody to Rat IGFBP3
– Western Blot Antibody to Rhesus IGFBP3
– Western Blot Antibody to Cynomolgus IGFBP3
– Western Blot Antibody to Canine (Dog) IGFBP3
– Western Blot Antibody to Ferret IGFBP3
– Western Blot Antibody to Bovine IGFBP3
Immunohistochemistry (IHC) Antibody to IGFBP3
– Immunohistochemistry (IHC) Antibody to Human IGFBP3
– Immunohistochemistry (IHC) Antibody to Mouse IGFBP3
– Immunohistochemistry (IHC) Antibody to Rat IGFBP3
– Immunohistochemistry (IHC) Antibody to Rhesus IGFBP3
– Immunohistochemistry (IHC) Antibody to Cynomolgus IGFBP3
– Immunohistochemistry (IHC) Antibody to Canine (Dog) IGFBP3
– Immunohistochemistry (IHC) Antibody to Ferret IGFBP3
– Immunohistochemistry (IHC) Antibody to Bovine IGFBP3
Flow Cytometry (FACS) Antibody to IGFBP3
– Flow Cytometry (FACS) Antibody to Human IGFBP3
– Flow Cytometry (FACS) Antibody to Mouse IGFBP3
– Flow Cytometry (FACS) Antibody to Rat IGFBP3
– Flow Cytometry (FACS) Antibody to Rhesus IGFBP3
– Flow Cytometry (FACS) Antibody to Cynomolgus IGFBP3
– Flow Cytometry (FACS) Antibody to Canine (Dog) IGFBP3
– Flow Cytometry (FACS) Antibody to Ferret IGFBP3
– Flow Cytometry (FACS) Antibody to Bovine IGFBP3
Additional IGFBP3 Products
Summary of IGFBP3 Protein, Antibody, ELISA Kit, cDNA Clone
The Insulin-like Growth Factor (IGF) signaling system plays a central role in cellular growth, differentiation and proliferation. IGFBP3 is the most abundant IGF binding protein in human serum and has been shown to be a growth inhibitory, apoptosis-inducing molecule, capable of acting via IGF-dependent and IGF-independent mechanisms. It appears to function both by cell cycle blockade and the induction of apoptosis. IGFBP3 can be transported to the nucleus by an importin beta mediated mechanism, where it has been shown to interact with the retinoid X receptor alpha and possibly other nuclear elements. IGFBP3 antiproliferative signalling appears to require an active transforming growth factor beta (TGF-beta) signalling pathway, and IGFBP3 stimulates phosphorylation of the TGF-beta signalling intermediates Smad2 and Smad3. IGFBP3 has IGF-independent roles in inhibiting cell proliferation in cancer cell lines. Nuclear transcription factor, retinoid X receptor (RXR)-alpha, and IGFBP3 functionally interact to reduce prostate tumor growth and prostate-specific antigen in vivo. Several clinical studies have proposed that individuals with IGFBP3 levels in the upper range of normal may have a decreased risk for certain common cancers. This includes evidence of a protective effect against breast cancer, prostate cancer, colorectal cancer, and lung cancer. Moreover, IGFBP3 inhibits insulin-stimulated glucose uptake into adipocytes independent of IGF.
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