WWP2 Protein

NEDD4-like E3 ubiquitin-protein ligase WWP2

WWP2 Products

WWP2 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
WWP2	Human	WWP2 Protein, Recombinant (with GST Tag)	13125-H20B

WWP2 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
WWP2	Human	Human WWP2 Gene cDNA Clone / ORF Clone	HG13125-G

WWP2 Related Areas

Enzyme >>Other>> WWP2

WWP2 Alternative Names

AIP2, WWp2-like, NEDD4-like E3 ubiquitin-protein ligase WWP2, Nedd-4-like ubiquitin-protein ligase, WW domain-containing protein 2, atrophin-1 interacting protein 2, atrophin-1-interacting protein 2 [Homo sapiens]

1300010O06Rik, AA690238, AIP2, AW554328, NEDD4-like E3 ubiquitin-protein ligase WWP2, WW domain-containing protein 2, WW domain-containing protein 4 [Mus musculus]

WWP2 Background

WWP2 contains 1 C2 domain, 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain and 4 WW domains. It is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. WWP2 can be detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. It is also expressed in spleen and peripheral blood leukocytes. WWP2 polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. WWP2 ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. It also ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. WWP2 ubiquitinates RPB1 and promotes it to proteasomal degradation.

WWP2 Related Studies

1. McDonald FJ, et al. (2002) Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel. Am J Physiol Renal Physiol. 283 (3): F431-6.
2. Soond SM, et al. (2011) Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT. Oncogene. 30 (21): 2451-62.
3. Marcucci R, et al. (2011) Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects. EMBO J. 30 (20): 4211-22.
4. Maddika S, et al. (2011) WWP2 is an E3 ubiquitin ligase for PTEN. Nat Cell Biol. 13 (6): 728-33.
5. Xu H, et al. (2009) WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells. Cell Res. 19 (5): 561-73.