WTAP Protein & Antibody

Wilms tumor 1 associated protein

WTAP Products

WTAP Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
WTAP	Human	WTAP Protein, Recombinant, with GST Tag	12018-H09E

WTAP Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human WTAP	WB, ELISA	WTAP Antibody (Antigen Affinity Purified)	12018-RP02

WTAP cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
WTAP	Human	Human WTAP cDNA Clone / ORF Clone	HG12018-G

WTAP Related Areas

Signal Transduction>>Transcription Factor & Regulator>>WTAP

WTAP Alternative Names

WTAP, RP1-56L9.4, DKFZp686F20131, KIAA0105, MGC3925 [Homo sapiens]

Wtap 2810408K05Rik, 9430038B09Rik [Mus musculus]

WTAP Background

Wilms' tumor 1-associating protein (WTAP) was previously identified as a protein associated with Wilms' tumor-1 (WT-1) protein that is essential for the development of the genitourinary system. WT1 was originally identified as a tumor suppressor for Wilms' tumor, but it is also overexpressed in a variety of cancer cells. The WTAP-WT1 axis in vascular cells suggest that WTAP is a vital and multifaceted regulator of vascular remodeling. WTAP has been suggested to function in alternative splicing, stabilization of mRNA, and cell growth. Knocking down endogenous WTAP increased Smooth muscle cells (SMCs) proliferation, because of increased DNA synthesis and G(1)/S phase transition, together with reduced apoptosis. These effects could be the result of WTAP suppressing the transcriptional activity of WT1 in SMCs. WTAP may thus also play a role in messenger RNA processing in mammalian cells, either dependent on or independent of its interaction with WT1.

WTAP Related Studies

1. Fukusumi Y, et al. (2008) Wtap is required for differentiation of endoderm and mesoderm in the mouse embryo. Dev Dyn. 237(3): 618-29.
2. Small TW, et al. (2007) Vascular biology and the sex of flies: regulation of vascular smooth muscle cell proliferation by wilms' tumor 1-associating protein. Trends Cardiovasc Med. 17(7): 230-4.
3. Small TW, et al. (2006) Wilms' tumor 1-associating protein regulates the proliferation of vascular smooth muscle cells. Circ Res. 99(12): 1338-46.
4. Rong Y, et al. (2006) Wilms' tumor 1 and signal transducers and activators of transcription 3 synergistically promote cell proliferation: a possible mechanism in sporadic Wilms' tumor. Cancer Res. 66(16): 8049-57.