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WTAP  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: E. coli  
20 µg 
100 µg 
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WTAP Related Area

WTAP Related Pathways

    WTAP Summary & Protein Information

    WTAP Background

    Gene Summary: The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. WTAP gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in three transcript variants, two of which encode the same isoform. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    Subunit structure: Component of the WMM complex, a N6-methyltransferase complex composed of WTAP, METTL3 and METTL14. Interacts with WT1. {ECO:0000269|PubMed:11001926, ECO:0000269|PubMed:17095724, ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421}.
    Subcellular location: Nucleus, nucleolus. Nucleus speckle.
    Tissue specificity: Ubiquitously expressed. {ECO:0000269|PubMed:11001926}.
    Induction: In smooth muscle cells, up-regulated after serum withdrawal, when cells become mature and non proliferative.
    Sequence similarity: Belongs to the fl(2)d family. {ECO:0000305}.
    General information above from UniProt

    Wilms' tumor 1-associating protein (WTAP) was previously identified as a protein associated with Wilms' tumor-1 (WT-1) protein that is essential for the development of the genitourinary system. WT1 was originally identified as a tumor suppressor for Wilms' tumor, but it is also overexpressed in a variety of cancer cells. The WTAP-WT1 axis in vascular cells suggest that WTAP is a vital and multifaceted regulator of vascular remodeling. WTAP has been suggested to function in alternative splicing, stabilization of mRNA, and cell growth. Knocking down endogenous WTAP increased Smooth muscle cells (SMCs) proliferation, because of increased DNA synthesis and G(1)/S phase transition, together with reduced apoptosis. These effects could be the result of WTAP suppressing the transcriptional activity of WT1 in SMCs. WTAP may thus also play a role in messenger RNA processing in mammalian cells, either dependent on or independent of its interaction with WT1.

    WTAP Alternative Name

    Mum2, [homo-sapiens]
    KIAA0105,MGC3925,DKFZp686F20131,RP1-56L9.4,WTAP, [human]
    9430038B09Rik,Wtap 2810408K05Rik, [mouse]
    2810408K05Rik,9430038B09Rik, [mus-musculus]

    WTAP Related Studies

  • Fukusumi Y, et al. (2008) Wtap is required for differentiation of endoderm and mesoderm in the mouse embryo. Dev Dyn. 237(3): 618-29.
  • Small TW, et al. (2007) Vascular biology and the sex of flies: regulation of vascular smooth muscle cell proliferation by wilms' tumor 1-associating protein. Trends Cardiovasc Med. 17(7): 230-4.
  • Small TW, et al. (2006) Wilms' tumor 1-associating protein regulates the proliferation of vascular smooth muscle cells. Circ Res. 99(12): 1338-46.
  • Rong Y, et al. (2006) Wilms' tumor 1 and signal transducers and activators of transcription 3 synergistically promote cell proliferation: a possible mechanism in sporadic Wilms' tumor. Cancer Res. 66(16): 8049-57.