WSX-1 (IL-27R)

The interleukin-27 receptor is a type I cytokine receptor for interleukin-27. It is a heterodimer composed of the interleukin 27 receptor, alpha subunit and glycoprotein 130. WSX-1/IL-27R, a class I cytokine receptor that is homologous to the β2 chain of the IL-12R in both sequence and structure, is highly expressed by resting/naive CD4+ T cells and CD8+ T cells. WSX-1/IL-27R belongs to the IL-6/IL-12 family of cytokines and induced proliferation of naive CD4(+) T cells and the generation of a Th1-type adaptive immune response. WSX-1/IL-27R functions as a receptor for IL27. IL-27 not only contributes to the development of an adaptive immune response through its action on CD4(+) T cells, it also directly acts on cells of the innate immune system. WSX-1/IL-27R requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. It is involved in the regulation of Th1-type immune responses. IL-27R also appears to be involved in innate defense mechanisms. IL27RA is essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation.

WSX-1 (IL-27R) Related Areas

Immunology>>Adaptive Immunity>>B Cell>>WSX-1/IL-27R

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-12 Family & Receptor>>WSX-1/IL-27R

Immunology>>Innate Immunity>>Mast Cell>>WSX-1/IL-27R

Immunology>>Innate Immunity>>Monocyte/Macrophage>>Macrophage Marker>>WSX-1/IL-27R

WSX-1 (IL-27R) Alternative Names

WSX1, IL27R, IL27RA, TCCR, CRL1, zcytor1 [Homo sapiens]

WSX-1, IL-27R, Il27ra, Tccr, Wsx1, CRL1, zcytor1 [Mus musculus]

Summaries for WSX-1 (IL-27R)

Entrez Gene summary for IL27RA:

In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.

OMIM - description for WSX-1:

Interleukin-27 (IL27) is a heterodimeric cytokine composed of p28 (IL27) and EBI3 subunits. WSX-1 (IL-27R) consists of the unique IL27RA chain and the common gp130 (IL6ST) chain, which is used by several other cytokines. IL-27R is widely expressed in the immune system, and IL27 can trigger signaling in T cells, B cells, and myeloid cells (Batten et al., 2006)

Wikipedia summary for WSX-1:

IL-27R is a type I cytokine receptor for interleukin-27. IL-27R is a heterodimer composed of the interleukin 27 receptor, alpha subunit and glycoprotein 130. IL27RA essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation.

Human WSX-1 (IL-27R) Protein General Information

 

• Protein names: Interleukin-27 receptor subunit alpha, Short name = IL-27RA
• Sequence length: 636 AA.
• Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation.
• Sequence similarities: WSX-1 belongs to the type I cytokine receptor family. Type 2 subfamily. WSX-1 contains 3 fibronectin type-III domains.
• Subcellular location: Membrane; Single-pass type I membrane protein.
• Tissue specificity: WSX-1 is highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. WSX-1 is weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes.

General information above from UniProt

Function for WSX-1 (IL-27R) Protein

UniProtKB:

IL-27R (WSX-1) is the receptor for IL27. WSX-1 requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. WSX-1 is involved in the regulation of Th1-type immune responses. WSX-1 also appears to be involved in innate defense mechanisms.

Genatlas:

• IL-27R (WSX-1) acts as a receptor for IL27
• WSX-1 requires IL6ST/gp130 to mediate signal transduction in response to IL27 (through STAT3 and STAT1)
• WSX-1 is involved in the regulation of Th1-type immune responses
• WSX-1 also appears to be involved in innate defense mechanisms
• WSX-1 can trigger signaling in T cells, B cells, and myeloid cells (Pubmed 16906167)
• WSX-1 possesses hematopoietic cell-transforming properties, can enhance activation of JAK2 and may be involved in myeloproliferative disorders (Pubmed 18003935)
• Both CNTFR and IL27RA may be involved in MTRNR2L1 binding to cells (Pubmed 19386761)
• WSX-1 is highly expressed in epithelial tumor cells where it inhibits tumor growth by enhancing natural killer cytolytic activity (Pubmed 19549909)

Homology for human WSX-1 (IL-27R)

• ortholog to murine Il27ra