WIF1 (WIF-1)

WIF1, also known as WIF-1 and wnt inhibitory factor 1, is a secreted protein which binds WNT proteins and inhibits their activities. It contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. WNT proteins are extracellular signaling molecules involved in the control of embryonic development. WIF1 may be involved in mesoderm segmentation and can be detected in fish, amphibia and mammals. WIF-1 is a recurrent target in human salivary gland oncogenesis. Downregulation of WIF1 takes part in the development and progression of pleomorphic adenomas. WIF1 also is a tumor suppressor, and has been found to be epigenetically silenced in various cancers, specifically in nonfunctioning pituitary tumors. WIF1 are expected to have molecular function (protein tyrosine kinase activity) and to localize in various compartments (extracellular space, extracellular region).

WIF1 (WIF-1) Related Areas

Stem Cell>>Wnt Signaling Pathway>>WIF1 / WIF-1 

Neuroscience>>Axon Guidance>>Wnt Signaling Pathway>>WIF1 / WIF-1

Signal Transduction>>Wnt Signaling Pathway>>WIF1 / WIF-1

WIF1 (WIF-1) Alternative Names

UNQ191/PRO217, WIF-1, wnt inhibitory factor 1 [Homo sapiens]

AW107799, WIF-1, wnt inhibitory factor 1 [Mus musculus]

Summaries for WIF1 (WIF-1)

Entrez Gene summary for WIF1 (WIF-1):

The protein encoded by WIF1 gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. WIF1 gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010]

Wikipedia summary for WIF1 (WIF-1):

Wnt inhibitory factor 1 is a lipid-binding protein that in humans is encoded by the WIF1 gene.
WNT proteins are extracellular signaling molecules involved in the control of embryonic development. This gene encodes a secreted protein, which binds WNT proteins and inhibits their activities. This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved in mesoderm segmentation. This protein is found to be present in fish, amphibia and mammals.

Human WIF1 (WIF-1) Protein General Information

 

• Protein names: Wnt inhibitory factor 1
  Short name=WIF1
• Sequence length: 379 AA.
• Domain: EGF-like domain
  Repeat
  Signal
• Sequence similarities: Contains 5 EGF-like domains.
  Contains 1 WIF domain.
• Subcellular location: Secreted.

General information above from UniProt

Function for WIF1 (WIF-1) Protein

UniProtKB:

WIF1 binds to WNT proteins and inhibits their activities. WIF1 may be involved in mesoderm segmentation.

Genatlas:

• WIF1 may be involved in mesoderm segmentation
• WIF1 is antagonist of the Wnt signaling pathway, which plays a critical role in the cancer
• Role of the WIF domain as a palmitoyl binding domain required for WIF1 binding to palmitoylated Wnt and signaling inhibition
• WIF1 is able to block WNT3a-mediated activation of the canonical Wnt signalling pathway
• WIF1 is novel extracellular Wnt modulator in cartilage biology
• WIF1 is downregulated by promoter methylation and functions as a tumor suppressor gene by inducing apoptosis in renal cell carcinoma cells
• WIF1 is negative regulator of the Wnt-signaling pathway that may have important implications for tumorigenesis