Anti-HE4 Antibody

Cat: 12609-RP01
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Anti-HE4 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-HE4 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human HE4
Immunogen
Recombinant Human WFDC2 / HE4 protein (Catalog#12609-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human WFDC2 / HE4 (rh WFDC2 / HE4; Catalog#12609-H08H; NP_006094.3; Met 1-Phe 124). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-HE4 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-HE4 Antibody Alternative Names
Anti-dJ461P17.6 Antibody;Anti-EDDM4 Antibody;Anti-HE4 Antibody;Anti-WAP5 Antibody
HE4 Background Information

WAP four-disulfide core domain protein 2, also known as Epididymal secretory protein E4, Major epididymis-specific protein E4, Putative protease inhibitor WAP5, WFDC2 and HE4, is a secreted protein which contains two WAP domains. WFDC2 / HE4 is a member of a family of stable 4-disulfide core proteins that are secreted at high levels. It is expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. It is highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis. WFDC2 may be a component of the innate immune defences of the lung, nasal and oral cavities and suggest that WFDC2 functions in concert with related WAP domain containing proteins in epithelial host defence. WFDC2 re-expression in lung carcinomas may prove to be associated with tumour type and should be studied in further detail. Mammary gland expression of tammar WFDC2 during the course of lactation showed WFDC2 was elevated during pregnancy, reduced in early lactation and absent in mid-late lactation. WFDC2 / HE4 can undergo a complex series of alternative splicing events that can potentially yield five distinct WAP domain containing protein isoforms.

Full Name
WAP four-disulfide core domain 2
References
  • Bingle,L. et al., 2002, Oncogene. 21 (17):2768-73.
  • Hellström,I. et al., 2003, Cancer Res. 63 (13):3695-700.
  • Bingle,L. et al., 2006, Respir Res. 7 : 61.
  • Galgano,M.T. et al., 2006, Mod Pathol.19 (6):847-53.
  • Sharp,J.A. et al., 2007, Evol Dev. 9 (4): 378-92.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-HE4 Antibody Rabbit Monoclonal IHC-P 80084-R004
    Anti-HE4 Antibody Rabbit Polyclonal ELISA,IHC-P 80084-T24
    Anti-HE4 Antibody Rabbit Polyclonal ELISA,IHC-P 12609-RP02
    Anti-HE4 Antibody Mouse Monoclonal ELISA 12609-MM15
    Anti-HE4 Antibody Mouse Monoclonal ELISA(Cap) 12609-MM12
    Anti-HE4 Antibody Rabbit Monoclonal IHC-P 12609-R404
    Anti-HE4 Antibody Rabbit Monoclonal ELISA,ELISA(Det) 12609-R108
    Anti-HE4 Antibody Rabbit Monoclonal ELISA 12609-R109
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