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vWF Antibody, Mouse MAb

  • vWF Antibody, Mouse MAb, Immunohistochemistry
  • vWF Antibody, Mouse MAb, Immunohistochemistry
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Human vWF Antibody Product Information
Immunogen:CHO cell-derived rhvWF (Catalog#10973-H08C)
Clone ID:7G2B11C10
Ig Type:Mouse IgG2a
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human von Willebrand factor (rhvWF; Catalog#10973-H08C; aa 1-2813; NP_000543.2). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Human vWF Antibody IHC Application Image
vWF Antibody, Mouse MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human vWF in human stomach with mouse monoclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to blood vessel.
vWF Antibody, Mouse MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human vWF in human tonsil with mouse monoclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to blood vessel.
Other vWF Antibody Products
Reactivity: Human  
Application: ELISA  
    10973-RP03-400
    10973-RP03-200
    10973-RP03-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  IHC-P  
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    10973-R111-50
    10973-R111-100
    50 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  IHC-P  
    • Slide 1
    10973-RP04-50
    10973-RP04-200
    10973-RP04-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    Immunochemical staining of human CCNF in human brain with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
    VWF/Von Willebrand Factor Background

    Von Willebrand Factor (VWF) is a multimeric glycoprotein involved in hemostasis in blood, binds receptors on the surface of platelets and in connective tissue, thereby mediating the adhesion of platelets to sites of vascular injury. From studies it appears that VWF protein uncoils under these circumstances, decelerating passing platelets. VWF protein is deficient or defective in von Willebrand disease (VWD) and is involved in a large number of other diseases, including thrombosis, thrombotic thrombocytopenic purpura, Stroke, Heyde's syndrome, possibly hemolytic-uremic syndrome and so on.

    Human VWF/Von Willebrand Factor References
  • Sadler JE. (1998) Biochemistry and genetics of von Willebrand factor. Annu Rev Biochem, 67: 395-424.
  • Batlle J, et al. (2009) Von Willebrand factor/factor VIII concentrates in the treatment of von Willebrand disease. Blood Coagul Fibrinolysis. 20(2):89-100.
  • Sadler JE. (2009) von Willebrand factor assembly and secretion. J Thromb Haemost. 7 Suppl 1:24-7.
  • Auton M, et al. (2010) The mechanism of VWF-mediated platelet GPIbalpha binding. Biophys J. 99(4):1192-201.
  • Bowen DJ. (2010) Sugar targets VWF for the chop. Blood. 115(13):2565.
  • Lpez JA, et al. (2010) VWF self-association: more bands for the buck. Blood. 116(19):3693-4.
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    Catalog: 10973-MM02-200
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    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"