Anti-Von Willebrand Factor Antibody (Rabbit Monoclonal antibody) General Information
Anti-Von Willebrand Factor Antibody
Reacts with: Human
Human Von Willebrand Factor
Recombinant Human vWF protein (Catalog#10973-H08C)
This antibody was obtained from a rabbit immunized with purified, recombinant Human von Willebrand factor (rh vWF; Catalog#10973-H08C; Met 1-Lys 2813; NP_000543.2)
Monoclonal Rabbit IgG Clone #111
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Von Willebrand Factor Antibody (Rabbit Monoclonal antibody) Validated Applications
||This antibody will detect Human VWF / Von Willebrand Factor in ELISA pair set (Catalog: # SEKA10973). In a sandwich ELISA, it can be used as detection antibody when paired with (Catalog: # 10973-MM05).
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-Von Willebrand Factor Antibody (Rabbit Monoclonal antibody) Images
Immunohistochemical staining of formalin fixed, paraffin-embedded human tonsil showing blood vessel staining (1:1000).
Immunohistochemical staining of formalin fixed, paraffin-embedded human stomach showing blood vessel staining (1:1000).
Immunohistochemical staining of formalin fixed, paraffin-embedded human muscle showing blood vessel staining (1:1000).
Immunohistochemical staining of formalin fixed, paraffin-embedded human lymphonode showing blood vessel staining (1:1000).
Anti-Von Willebrand Factor Antibody Alternative Names
Anti-F8VWF Antibody;Anti-Von Willebrand Factor Antibody;Anti-VWD Antibody
Von Willebrand Factor Background Information
Von Willebrand Factor (VWF) is a multimeric glycoprotein involved in hemostasis in blood, binds receptors on the surface of platelets and in connective tissue, thereby mediating the adhesion of platelets to sites of vascular injury. From studies it appears that VWF protein uncoils under these circumstances, decelerating passing platelets. VWF protein is deficient or defective in von Willebrand disease (VWD) and is involved in a large number of other diseases, including thrombosis, thrombotic thrombocytopenic purpura, Stroke, Heyde's syndrome, possibly hemolytic-uremic syndrome and so on.
von Willebrand factor
Sadler JE. (1998) Biochemistry and genetics of von Willebrand factor. Annu Rev Biochem, 67: 395-424.Batlle J, et al. (2009) Von Willebrand factor/factor VIII concentrates in the treatment of von Willebrand disease. Blood Coagul Fibrinolysis. 20(2):89-100.Sadler JE. (2009) von Willebrand factor assembly and secretion. J Thromb Haemost. 7 Suppl 1:24-7.Auton M, et al. (2010) The mechanism of VWF-mediated platelet GPIbalpha binding. Biophys J. 99(4):1192-201.Bowen DJ. (2010) Sugar targets VWF for the chop. Blood. 115(13):2565.Lpez JA, et al. (2010) VWF self-association: more bands for the buck. Blood. 116(19):3693-4.