Vitronectin Protein & Antibody

Vitronectin Products

Vitronectin Protein, Recombinant

Molecule	Species	Description	Cat. No
Vitronectin	Human	Vitronectin Protein, Recombinant	10424-H07H
Vitronectin	Mouse	Vitronectin Protein, Recombinant	50585-M08H

  10424-H07H:  When cells are added to Vitronectin coated plates (5 µg/mL and 100 µL/well), approximately 80-90% will adhere specifically after 30 minutes at 37 ℃. Measured by the ability of the immobilized protein to support the adhesion of DU145 human prostate carcinoma cells.

Vitronectin Antibody

Molecule	Application	Description	Cat. No
Human Vitronectin	WB, ELISA	Vitronectin Antibody, Mouse MAb	10424-MM11
Mouse Vitronectin	WB, ELISA	Vitronectin Antibody, Rabbit PAb	50585-RP02

Vitronectin ELISA Kit

Molecule	Application	Description	Cat. No
Human Vitronectin	ELISA	Vitronectin ELISA Kit	SEK10424

Vitronectin cDNA Clone

Molecule	Species	Description	Cat. No
Vitronectin	Human	Homo sapiens Vitronectin cDNA Clone(NM_000638.3)	HG10424-M
Vitronectin	Mouse	Mus musculus Vitronectin cDNA Clone	MG50585-M

Vitronectin Related Areas

Cancer>>Angiogenesis>>ECM Molecules in Angiogenesis>>Vitronectin

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Extracellular Matrix Protein>>Vitronectin

Vitronectin Alternative Names

Vitronectin, VTN, V75, VN, VNT [Homo sapiens]

Vitronectin, Vtn, RP23-399H5.3, AI256434, Vn [Mus musculus]

Vitronectin Background

Vitronectin, also known as VTN, is a member of the pexin family. It is an abundant glycoprotein found in serum the extracellular matrix and promotes cell adhesion and spreading. Vitronectin is a secreted protein and exists in either a single chain form or a cleaved, two chain form held together by a disulfide bond. Vitronectin is a plasma glycoprotein implicated as a regulator of diverse physiological process, including blood coagulation, fibrinolysis, pericellular proteolysis, complement dependent immune responses, and cell attachment and spreading. Because of its ability to bind platelet glycoproteins and mediate platelet adhesion and aggregation at sites of vascular injury, vitronectin has become an important mediator in the pathogenesis of coronary atherosclerosis. As a multifunctional protein with a multiple binding domain, Vitronectin interacts with a variety of plasma and cell proteins. Vitronectin binds multiple ligands, including the soluble vitronectin receptor. It may be an independent predictor of adverse cardiovascular outcomes following acute stenting. Accordingly, Vitronectin is suggested to be involved in hemostasis, cell migration, as well as tumor malignancy.

Vitronectin Related Studies

1. Ekmekçi OB, et al. (2006) Vitronectin in atherosclerotic disease. Clin Chim Acta. 368(1-2): 77-83.
2. Derer W, et al. (2009) Vitronectin concentrations predict risk in patients undergoing coronary stenting. Circ Cardiovasc Interv. 2(1): 14-9.
3. Heyman L, et al. (2010) Mesothelial vitronectin stimulates migration of ovarian cancer cells. Cell Biol Int. 34(5): 493-502.