Anti-Vitronectin Antibody

Cat: 10424-MM11
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All Vitronectin Reagents
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All Vitronectin Reagents
Anti-Vitronectin Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-Vitronectin Antibody
Validated applications
ELISA,ELISA(Cap)
Species reactivity
Reacts with: Human
Specificity
Human Vitronectin
Immunogen
Recombinant Human VTN protein (Catalog#10424-H07H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Vitronectin (rh Vitronectin; Catalog#10424-H07H; NP_000629.3; Asp 20-Leu 478). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography .
Source
Monoclonal Mouse IgG2a Clone #5G11B10D7
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Vitronectin Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  
ELISA(Cap) 1:250-1:2000 This antibody will detect Human Vitronectin / VTN in ELISA pair set (Catalog: # SEK10424). In a sandwich ELISA, it can be used as capture antibody when paired with (Catalog: # 10424-MM03).

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Vitronectin Antibody Alternative Names
Anti-V75 Antibody;Anti-Vitronectin Antibody;Anti-VN Antibody;Anti-VNT Antibody
Vitronectin Background Information

Vitronectin, also known as VTN, is a member of the pexin family. It is an abundant glycoprotein found in serum the extracellular matrix and promotes cell adhesion and spreading. Vitronectin is a secreted protein and exists in either a single chain form or a cleaved, two chain form held together by a disulfide bond. Vitronectin is a plasma glycoprotein implicated as a regulator of diverse physiological process, including blood coagulation, fibrinolysis, pericellular proteolysis, complement dependent immune responses, and cell attachment and spreading. Because of its ability to bind platelet glycoproteins and mediate platelet adhesion and aggregation at sites of vascular injury, vitronectin has become an important mediator in the pathogenesis of coronary atherosclerosis. As a multifunctional protein with a multiple binding domain, Vitronectin interacts with a variety of plasma and cell proteins. Vitronectin binds multiple ligands, including the soluble vitronectin receptor. It may be an independent predictor of adverse cardiovascular outcomes following acute stenting. Accordingly, Vitronectin is suggested to be involved in hemostasis, cell migration, as well as tumor malignancy.

Full Name
vitronectin
References
  • Ekmeki OB, et al. (2006) Vitronectin in atherosclerotic disease. Clin Chim Acta. 368(1-2): 77-83.
  • Derer W, et al. (2009) Vitronectin concentrations predict risk in patients undergoing coronary stenting. Circ Cardiovasc Interv. 2(1): 14-9.
  • Heyman L, et al. (2010) Mesothelial vitronectin stimulates migration of ovarian cancer cells. Cell Biol Int. 34(5): 493-502.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Vitronectin Antibody Rabbit Polyclonal ELISA 50585-RP01
    Anti-Vitronectin Antibody Rabbit Monoclonal ELISA,IHC-P 50585-R019
    Anti-Vitronectin Antibody Rabbit Polyclonal ELISA,IHC-P 50585-RP02
    Anti-Vitronectin Antibody Rabbit Monoclonal ELISA 10424-R102
    Anti-Vitronectin Antibody Mouse Monoclonal ELISA(Det) 10424-MM03
    Anti-Vitronectin Antibody Rabbit Monoclonal ELISA 10424-R103
    Anti-Vitronectin Antibody Rabbit Polyclonal WB,ELISA 10424-RP01
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