Vaspin (SerpinA12)

Vaspin may modulates insulin action conceivably only in the presence of its yet undefined target proteases in white adipose tissues.

Vaspin (SerpinA12) Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Serpin Superfamily>>Vaspin/SerpinA12

Vaspin (SerpinA12) Alternative Names

Vaspin, SerpinA12, OL-64 [Homo sapiens] Vaspin, SerpinA12, 4632419J12Rik [Mus musculus]

Human Vaspin (SerpinA12) Protein General Information

 

• Protein names: Visceral adipose tissue-derived serine protease inhibitor
  Short name=Vaspin
• Sequence length: 414 AA.
• Domain: Signal
• Sequence similarities: Belongs to the serpin family.
• Subcellular location: Secreted.
• Tissue specificity: Expressed in visceral adipose tissues.

General information above from UniProt

Function for Vaspin (SerpinA12) Protein

UniProtKB:

Vaspin may modulates insulin action conceivably only in the presence of its yet undefined target proteases in white adipose tissues.

Genatlas:

• Vaspin is adipokine with insulin-sensitizing effects, which is predominantly secreted from visceral adipose tissue in diabetes (Youn 2008)
• Vaspin exerts an insulin-sensitizing effect targeted toward visceral white adipose tissues in states of obesity
• Vaspin may be involved in the regulation of placental metabolic functions (Caminos 2009)
• Vaspin acts as regulator of insulin sensitivity but also as mediators of the inflammatory process (Kukla 2010)